PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES
A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents -CH2-, -C(O)-, or -C(O)NH...
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| creator | KAROLINA DZWONEK PAULINA GRYGIELEWICZ ABDELLAH YAMANI JOANNA LIPNER MONIKA LAMPARSKA-PRZYBYSZ ALEKSANDRA STANCZAK DARIA ZDZALIK MACIEJ WIECZOREK KRZYSZTOF DUBIEL |
| description | A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents -CH2-, -C(O)-, or -C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, -(CH2)l-NR2R3, or -(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, -NH-or -N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I) |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PT2970210TT</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PT2970210TT</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PT2970210TT3</originalsourceid><addsrcrecordid>eNrjZFALiAxyjPL3ifRxcvWL8o92ifX09XQBibgquLgGeYY5hniGuQbzMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4gBAjS3MDI0ODkBBjIpQAAObDJH0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><source>esp@cenet</source><creator>KAROLINA DZWONEK ; PAULINA GRYGIELEWICZ ; ABDELLAH YAMANI ; JOANNA LIPNER ; MONIKA LAMPARSKA-PRZYBYSZ ; ALEKSANDRA STANCZAK ; DARIA ZDZALIK ; MACIEJ WIECZOREK ; KRZYSZTOF DUBIEL</creator><creatorcontrib>KAROLINA DZWONEK ; PAULINA GRYGIELEWICZ ; ABDELLAH YAMANI ; JOANNA LIPNER ; MONIKA LAMPARSKA-PRZYBYSZ ; ALEKSANDRA STANCZAK ; DARIA ZDZALIK ; MACIEJ WIECZOREK ; KRZYSZTOF DUBIEL</creatorcontrib><description>A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents -CH2-, -C(O)-, or -C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, -(CH2)l-NR2R3, or -(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, -NH-or -N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170407&DB=EPODOC&CC=PT&NR=2970210T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170407&DB=EPODOC&CC=PT&NR=2970210T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAROLINA DZWONEK</creatorcontrib><creatorcontrib>PAULINA GRYGIELEWICZ</creatorcontrib><creatorcontrib>ABDELLAH YAMANI</creatorcontrib><creatorcontrib>JOANNA LIPNER</creatorcontrib><creatorcontrib>MONIKA LAMPARSKA-PRZYBYSZ</creatorcontrib><creatorcontrib>ALEKSANDRA STANCZAK</creatorcontrib><creatorcontrib>DARIA ZDZALIK</creatorcontrib><creatorcontrib>MACIEJ WIECZOREK</creatorcontrib><creatorcontrib>KRZYSZTOF DUBIEL</creatorcontrib><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><description>A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents -CH2-, -C(O)-, or -C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, -(CH2)l-NR2R3, or -(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, -NH-or -N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFALiAxyjPL3ifRxcvWL8o92ifX09XQBibgquLgGeYY5hniGuQbzMLCmJeYUp_JCaW4GBTfXEGcP3dSC_PjU4oLE5NS81JL4gBAjS3MDI0ODkBBjIpQAAObDJH0</recordid><startdate>20170407</startdate><enddate>20170407</enddate><creator>KAROLINA DZWONEK</creator><creator>PAULINA GRYGIELEWICZ</creator><creator>ABDELLAH YAMANI</creator><creator>JOANNA LIPNER</creator><creator>MONIKA LAMPARSKA-PRZYBYSZ</creator><creator>ALEKSANDRA STANCZAK</creator><creator>DARIA ZDZALIK</creator><creator>MACIEJ WIECZOREK</creator><creator>KRZYSZTOF DUBIEL</creator><scope>EVB</scope></search><sort><creationdate>20170407</creationdate><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><author>KAROLINA DZWONEK ; PAULINA GRYGIELEWICZ ; ABDELLAH YAMANI ; JOANNA LIPNER ; MONIKA LAMPARSKA-PRZYBYSZ ; ALEKSANDRA STANCZAK ; DARIA ZDZALIK ; MACIEJ WIECZOREK ; KRZYSZTOF DUBIEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT2970210TT3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; por</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KAROLINA DZWONEK</creatorcontrib><creatorcontrib>PAULINA GRYGIELEWICZ</creatorcontrib><creatorcontrib>ABDELLAH YAMANI</creatorcontrib><creatorcontrib>JOANNA LIPNER</creatorcontrib><creatorcontrib>MONIKA LAMPARSKA-PRZYBYSZ</creatorcontrib><creatorcontrib>ALEKSANDRA STANCZAK</creatorcontrib><creatorcontrib>DARIA ZDZALIK</creatorcontrib><creatorcontrib>MACIEJ WIECZOREK</creatorcontrib><creatorcontrib>KRZYSZTOF DUBIEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAROLINA DZWONEK</au><au>PAULINA GRYGIELEWICZ</au><au>ABDELLAH YAMANI</au><au>JOANNA LIPNER</au><au>MONIKA LAMPARSKA-PRZYBYSZ</au><au>ALEKSANDRA STANCZAK</au><au>DARIA ZDZALIK</au><au>MACIEJ WIECZOREK</au><au>KRZYSZTOF DUBIEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES</title><date>2017-04-07</date><risdate>2017</risdate><abstract>A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen atoms of the pyrazole or benzimidazole ring, respectively; R1 represents -X-Q-P, wherein X is absent or represents -CH2-, -C(O)-, or -C(O)NH-(CH2)k-, wherein k is 0, 1 or 2; Q is selected from the group consisting of Q1, Q2, Q3, Q4 and Q5; P is absent or represents straight- or branched-chain C1-C3 alkyl, -(CH2)l-NR2R3, or -(CH2)m-C(O)-NR2R3, wherein l and m independently of each other represent 0, 1 or 2, with the proviso that when B in Q1 represents oxygen atom, then P is absent; and R2 and R3 independently represent C1 or C2 alkyl, or R2 and R3 together with nitrogen atom to which they are both attached form a 6-membered saturated heterocyclic ring, wherein one of carbon atoms can be replaced with oxygen, -NH-or -N(C1-C2)alkyl-; and acid addition salts thereof. The compound can be useful in the treatment of cancer diseases. (I)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRAZOLYLBENZO[D]IMIDAZOLE DERIVATIVES |
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