SPIROCYCLIC AMILORIDE ANALOGUES AS ENAC BLOCKERS
A compound of Formula I in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airwa...
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| creator | CATHERINE HOWSHAM PAUL OAKLEY EMMA BUDD PETER HUNT NICHOLA SMITH GURDIP BHALAY STEPHEN PAUL COLLINGWOOD ANDREW DUNSTAN LEE EDWARDS PETER GEDECK GRAHAM CHARLES BLOOMFIELD THOMAS ANTHONY HUNT |
| description | A compound of Formula I
in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airway diseases like COPD and cystic fibrosis are treatable, but also inflammatory and allergic diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. |
| format | Patent |
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in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airway diseases like COPD and cystic fibrosis are treatable, but also inflammatory and allergic diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180103&DB=EPODOC&CC=PT&NR=2444120T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180103&DB=EPODOC&CC=PT&NR=2444120T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CATHERINE HOWSHAM</creatorcontrib><creatorcontrib>PAUL OAKLEY</creatorcontrib><creatorcontrib>EMMA BUDD</creatorcontrib><creatorcontrib>PETER HUNT</creatorcontrib><creatorcontrib>NICHOLA SMITH</creatorcontrib><creatorcontrib>GURDIP BHALAY</creatorcontrib><creatorcontrib>STEPHEN PAUL COLLINGWOOD</creatorcontrib><creatorcontrib>ANDREW DUNSTAN</creatorcontrib><creatorcontrib>LEE EDWARDS</creatorcontrib><creatorcontrib>PETER GEDECK</creatorcontrib><creatorcontrib>GRAHAM CHARLES BLOOMFIELD</creatorcontrib><creatorcontrib>THOMAS ANTHONY HUNT</creatorcontrib><title>SPIROCYCLIC AMILORIDE ANALOGUES AS ENAC BLOCKERS</title><description>A compound of Formula I
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in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. In particular, airway diseases like COPD and cystic fibrosis are treatable, but also inflammatory and allergic diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | SPIROCYCLIC AMILORIDE ANALOGUES AS ENAC BLOCKERS |
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