PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY
This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of (i) fentanyl or a pharmaceutically acceptable salt thereof and (ii) a pectin having a degree of esterification (DE value) of less than 30% pr...
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| creator | CASTILE JONATHAN DAVID LAFFERTY WILLIAM COLUMBUS IAN SMITH ALAN WATTS PETER JAMES |
| description | This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. |
| format | Patent |
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(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</description><language>eng ; por</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190524&DB=EPODOC&CC=PT&NR=2436375T$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190524&DB=EPODOC&CC=PT&NR=2436375T$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CASTILE JONATHAN DAVID</creatorcontrib><creatorcontrib>LAFFERTY WILLIAM COLUMBUS IAN</creatorcontrib><creatorcontrib>SMITH ALAN</creatorcontrib><creatorcontrib>WATTS PETER JAMES</creatorcontrib><title>PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY</title><description>This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAP8HAM8nV0dg0N8XR29FFw9vcN8A_2DPH09wsGc4I8gz393BXcXP1CHP0ifRTc_IMUPP1Cghz9HIOB6l1cfTzDXIMieRhY0xJzilN5oTQ3A1BLiLOHbmpBfnxqcUFicmpeakl8QIiRibGZsblpSIgxEUoA3SwtWg</recordid><startdate>20190524</startdate><enddate>20190524</enddate><creator>CASTILE JONATHAN DAVID</creator><creator>LAFFERTY WILLIAM COLUMBUS IAN</creator><creator>SMITH ALAN</creator><creator>WATTS PETER JAMES</creator><scope>EVB</scope></search><sort><creationdate>20190524</creationdate><title>PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY</title><author>CASTILE JONATHAN DAVID ; LAFFERTY WILLIAM COLUMBUS IAN ; SMITH ALAN ; WATTS PETER JAMES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT2436375TT3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; por</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CASTILE JONATHAN DAVID</creatorcontrib><creatorcontrib>LAFFERTY WILLIAM COLUMBUS IAN</creatorcontrib><creatorcontrib>SMITH ALAN</creatorcontrib><creatorcontrib>WATTS PETER JAMES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CASTILE JONATHAN DAVID</au><au>LAFFERTY WILLIAM COLUMBUS IAN</au><au>SMITH ALAN</au><au>WATTS PETER JAMES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY</title><date>2019-05-24</date><risdate>2019</risdate><abstract>This invention provides a composition for intranasal delivery for the treatment or prevention of acute or chronic pain, which comprises an aqueous solution of
(i) fentanyl or a pharmaceutically acceptable salt thereof and
(ii) a pectin having a degree of esterification (DE value) of less than 30%
provided that the composition is substantially free of divalent metal ions;
and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (C max ) that is from 20 to 75% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PHARMACEUTICAL COMPOSITIONS COMPRISING FENTANYL FOR INTRANASAL DELIVERY |
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