3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND
A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydro...
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| creator | YOSHINORI TAKAHASHI KUNITOSHI TAKEDA HISASHI SHIBATA KOGYOKU SHIN KODO SHIKATA AKIRA INOMATA TARO TERAUCHI MINAKO HASHIZUME |
| description | A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug.
wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2-ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R 4 represents methoxy or chlorine. |
| format | Patent |
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wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2-ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R 4 represents methoxy or chlorine.</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121227&DB=EPODOC&CC=PT&NR=2266990E$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121227&DB=EPODOC&CC=PT&NR=2266990E$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YOSHINORI TAKAHASHI</creatorcontrib><creatorcontrib>KUNITOSHI TAKEDA</creatorcontrib><creatorcontrib>HISASHI SHIBATA</creatorcontrib><creatorcontrib>KOGYOKU SHIN</creatorcontrib><creatorcontrib>KODO SHIKATA</creatorcontrib><creatorcontrib>AKIRA INOMATA</creatorcontrib><creatorcontrib>TARO TERAUCHI</creatorcontrib><creatorcontrib>MINAKO HASHIZUME</creatorcontrib><title>3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND</title><description>A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug.
wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2-ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R 4 represents methoxy or chlorine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAw1g3wcPWL9AmIDHKM8vfxjzbVMdR1ig3x8ARxXRWc_X0D_EP9XHgYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSXxAiJGRmZmlpYGrqzERSgDppyRX</recordid><startdate>20121227</startdate><enddate>20121227</enddate><creator>YOSHINORI TAKAHASHI</creator><creator>KUNITOSHI TAKEDA</creator><creator>HISASHI SHIBATA</creator><creator>KOGYOKU SHIN</creator><creator>KODO SHIKATA</creator><creator>AKIRA INOMATA</creator><creator>TARO TERAUCHI</creator><creator>MINAKO HASHIZUME</creator><scope>EVB</scope></search><sort><creationdate>20121227</creationdate><title>3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND</title><author>YOSHINORI TAKAHASHI ; KUNITOSHI TAKEDA ; HISASHI SHIBATA ; KOGYOKU SHIN ; KODO SHIKATA ; AKIRA INOMATA ; TARO TERAUCHI ; MINAKO HASHIZUME</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT2266990EE3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; por</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YOSHINORI TAKAHASHI</creatorcontrib><creatorcontrib>KUNITOSHI TAKEDA</creatorcontrib><creatorcontrib>HISASHI SHIBATA</creatorcontrib><creatorcontrib>KOGYOKU SHIN</creatorcontrib><creatorcontrib>KODO SHIKATA</creatorcontrib><creatorcontrib>AKIRA INOMATA</creatorcontrib><creatorcontrib>TARO TERAUCHI</creatorcontrib><creatorcontrib>MINAKO HASHIZUME</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YOSHINORI TAKAHASHI</au><au>KUNITOSHI TAKEDA</au><au>HISASHI SHIBATA</au><au>KOGYOKU SHIN</au><au>KODO SHIKATA</au><au>AKIRA INOMATA</au><au>TARO TERAUCHI</au><au>MINAKO HASHIZUME</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND</title><date>2012-12-27</date><risdate>2012</risdate><abstract>A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug.
wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2-ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R 4 represents methoxy or chlorine.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND |
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