SMALL PEPTIDES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER BETA-AMYLOID PROTEIN FIBRILLOGENESIS DISORDERS

A composition of matter that includes the peptide sequence Arg-Val-Ala-Val-Ile-Met-Gly-amide (Dp-068). A pharmaceutical composition that includes peptide Arg-Val-Ala-Val-Ile-Met-Gly-amide (Dp-068). Use of the peptide for preparation of a medicament for the treatment of a diseases characterized by A²...

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Bibliographische Detailangaben
Hauptverfasser:	BETH P. NGUYEN, GERARDO M. CASTILLO, THOMAS P. LAKE, VIRGINIA J. SANDERS, ALAN D. SNOW
Format:	Patent
Sprache:	eng ; por
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TESTING TRAPPING
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Beschreibung
Zusammenfassung:	A composition of matter that includes the peptide sequence Arg-Val-Ala-Val-Ile-Met-Gly-amide (Dp-068). A pharmaceutical composition that includes peptide Arg-Val-Ala-Val-Ile-Met-Gly-amide (Dp-068). Use of the peptide for preparation of a medicament for the treatment of a diseases characterized by A² fibrillogenesis. Use of an aantibody directed against a peptide comprising Arg-Val-Ala-Val-Ile-Met-Gly-amide in the manufacture of a medicament for the treatment of a disease characterized by A² fibrillogenesis. Preferably where at least one amino acid of the peptide sequence is a D-amino acid.