PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE
Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (I) involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III)...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; por |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | RAINER SOBOTTA WOLFGANG BROEDER |
| description | Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (I) involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of (IV) (V), which is converted to (I). Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (I) optionally in the form of its acid addition salt involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (V), which is converted to (I). An independent claim is included for new intermediate hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (V). [Image]. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PT2118090EE</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PT2118090EE</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PT2118090EE3</originalsourceid><addsrcrecordid>eNrjZLAMCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTcFRwcvWL8vT1dHGM8vdxVXBxDfIMA8qGufIwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUkviAECNDQwsDSwNXV2MilAAARJ0oog</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE</title><source>esp@cenet</source><creator>RAINER SOBOTTA ; WOLFGANG BROEDER</creator><creatorcontrib>RAINER SOBOTTA ; WOLFGANG BROEDER</creatorcontrib><description>Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (I) involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of (IV) (V), which is converted to (I). Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (I) optionally in the form of its acid addition salt involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (V), which is converted to (I). An independent claim is included for new intermediate hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (V). [Image].</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100831&DB=EPODOC&CC=PT&NR=2118090E$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100831&DB=EPODOC&CC=PT&NR=2118090E$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAINER SOBOTTA</creatorcontrib><creatorcontrib>WOLFGANG BROEDER</creatorcontrib><title>PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE</title><description>Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (I) involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of (IV) (V), which is converted to (I). Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (I) optionally in the form of its acid addition salt involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (V), which is converted to (I). An independent claim is included for new intermediate hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (V). [Image].</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTcFRwcvWL8vT1dHGM8vdxVXBxDfIMA8qGufIwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUkviAECNDQwsDSwNXV2MilAAARJ0oog</recordid><startdate>20100831</startdate><enddate>20100831</enddate><creator>RAINER SOBOTTA</creator><creator>WOLFGANG BROEDER</creator><scope>EVB</scope></search><sort><creationdate>20100831</creationdate><title>PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE</title><author>RAINER SOBOTTA ; WOLFGANG BROEDER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT2118090EE3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; por</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>RAINER SOBOTTA</creatorcontrib><creatorcontrib>WOLFGANG BROEDER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RAINER SOBOTTA</au><au>WOLFGANG BROEDER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE</title><date>2010-08-31</date><risdate>2010</risdate><abstract>Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (I) involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of (IV) (V), which is converted to (I). Preparation of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (I) optionally in the form of its acid addition salt involves reacting 3-[(3-amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester (II) with (4-cyano-phenylamino)-acetic acid (III) in presence of coupling agent to form 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (IV), which is converted without isolation into hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester of formula (V), which is converted to (I). An independent claim is included for new intermediate hydrobromide salt of 3-({2-[(4-cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester (V). [Image].</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; por |
| recordid | cdi_epo_espacenet_PT2118090EE |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR THE PREPARATION OF A BENZIMIDAZOLE DERIVATIVE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A40%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RAINER%20SOBOTTA&rft.date=2010-08-31&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EPT2118090EE%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |