METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT
Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, a...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; por |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | BAHIJA JALLAL SHARON LEA AUKERMAN MOHAMMAD LUQMAN |
| description | Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PT1889065EE</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PT1889065EE</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PT1889065EE3</originalsourceid><addsrcrecordid>eNqNy0EKwkAMheFuXIh6h1xAVETRZWgz7YBJSicVXJUq40q0UO-PI3gAV2_xvn-aXZms0iKA0wYKj6Vo8AFQCrCG0JjEQF26AmGgABWevZQJALamnrkV-vJV6r24EzKjaXOBXLlWSfk8m9z7xxgXv51l4MjyahmHVxfHob_FZ3x3tW0Oh-N6vyPa_kE-irw0Cw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT</title><source>esp@cenet</source><creator>BAHIJA JALLAL ; SHARON LEA AUKERMAN ; MOHAMMAD LUQMAN</creator><creatorcontrib>BAHIJA JALLAL ; SHARON LEA AUKERMAN ; MOHAMMAD LUQMAN</creatorcontrib><description>Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.</description><language>eng ; por</language><subject>HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; PHYSICS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130927&DB=EPODOC&CC=PT&NR=1889065E$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130927&DB=EPODOC&CC=PT&NR=1889065E$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BAHIJA JALLAL</creatorcontrib><creatorcontrib>SHARON LEA AUKERMAN</creatorcontrib><creatorcontrib>MOHAMMAD LUQMAN</creatorcontrib><title>METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT</title><description>Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PHYSICS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy0EKwkAMheFuXIh6h1xAVETRZWgz7YBJSicVXJUq40q0UO-PI3gAV2_xvn-aXZms0iKA0wYKj6Vo8AFQCrCG0JjEQF26AmGgABWevZQJALamnrkV-vJV6r24EzKjaXOBXLlWSfk8m9z7xxgXv51l4MjyahmHVxfHob_FZ3x3tW0Oh-N6vyPa_kE-irw0Cw</recordid><startdate>20130927</startdate><enddate>20130927</enddate><creator>BAHIJA JALLAL</creator><creator>SHARON LEA AUKERMAN</creator><creator>MOHAMMAD LUQMAN</creator><scope>EVB</scope></search><sort><creationdate>20130927</creationdate><title>METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT</title><author>BAHIJA JALLAL ; SHARON LEA AUKERMAN ; MOHAMMAD LUQMAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT1889065EE3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; por</language><creationdate>2013</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PHYSICS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>BAHIJA JALLAL</creatorcontrib><creatorcontrib>SHARON LEA AUKERMAN</creatorcontrib><creatorcontrib>MOHAMMAD LUQMAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BAHIJA JALLAL</au><au>SHARON LEA AUKERMAN</au><au>MOHAMMAD LUQMAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT</title><date>2013-09-27</date><risdate>2013</risdate><abstract>Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor ex vivo response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The ex vivo prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor in vivo efficacy of treatment with an anti-CD40 therapeutic agent.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; por |
| recordid | cdi_epo_espacenet_PT1889065EE |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES HAVING AN AUTOIMMUNE AND/OR INFLAMMATORY COMPONENT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T09%3A44%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=BAHIJA%20JALLAL&rft.date=2013-09-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EPT1889065EE%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |