3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionall...
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| creator | GABOR SZENASI LASZLO GABOR HARSING GYULA SIMIG NORA SZIRAY ENDRENE FLORIAN ISTVAN GACSALYI RITA KAPILLERNE DEZSOFI KRISZTINA MORICZ BALAZS VOLK KATALIN PALLAGI TIBOR MEZEI ANDRAS EGYED JOZSEF BARKOCZY CSILLA LEVELEKI GYOERGY LEVAY GABOR GIGLER |
| description | The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system. |
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ISTVAN GACSALYI ; RITA KAPILLERNE DEZSOFI ; KRISZTINA MORICZ ; BALAZS VOLK ; KATALIN PALLAGI ; TIBOR MEZEI ; ANDRAS EGYED ; JOZSEF BARKOCZY ; CSILLA LEVELEKI ; GYOERGY LEVAY ; GABOR GIGLER</creator><creatorcontrib>GABOR SZENASI ; LASZLO GABOR HARSING ; GYULA SIMIG ; NORA SZIRAY ; ENDRENE FLORIAN ; ISTVAN GACSALYI ; RITA KAPILLERNE DEZSOFI ; KRISZTINA MORICZ ; BALAZS VOLK ; KATALIN PALLAGI ; TIBOR MEZEI ; ANDRAS EGYED ; JOZSEF BARKOCZY ; CSILLA LEVELEKI ; GYOERGY LEVAY ; GABOR GIGLER</creatorcontrib><description>The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.</description><language>eng ; por</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090916&DB=EPODOC&CC=PT&NR=1776339E$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090916&DB=EPODOC&CC=PT&NR=1776339E$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GABOR SZENASI</creatorcontrib><creatorcontrib>LASZLO GABOR HARSING</creatorcontrib><creatorcontrib>GYULA SIMIG</creatorcontrib><creatorcontrib>NORA SZIRAY</creatorcontrib><creatorcontrib>ENDRENE FLORIAN</creatorcontrib><creatorcontrib>ISTVAN GACSALYI</creatorcontrib><creatorcontrib>RITA KAPILLERNE DEZSOFI</creatorcontrib><creatorcontrib>KRISZTINA MORICZ</creatorcontrib><creatorcontrib>BALAZS VOLK</creatorcontrib><creatorcontrib>KATALIN PALLAGI</creatorcontrib><creatorcontrib>TIBOR MEZEI</creatorcontrib><creatorcontrib>ANDRAS EGYED</creatorcontrib><creatorcontrib>JOZSEF BARKOCZY</creatorcontrib><creatorcontrib>CSILLA LEVELEKI</creatorcontrib><creatorcontrib>GYOERGY LEVAY</creatorcontrib><creatorcontrib>GABOR GIGLER</creatorcontrib><title>3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS</title><description>The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzDFqAzEQBdBtUgQnd5hyDZlirWDjUqxmkYhWI0bjhXVjTFCqkBjsA_mosUkOkOr9D5__2FwNtm37itlTmuMSc8gkdh8SdnjvNr7dMb8BuxeDLvjZCePKY0iOI66QE4EjCZPVMFEBmxwIRavkoOcx8y65AgMLqCdQIasjJQUeoL8pNkIimXhXoMxFaQQXCsvtsjw1Dx_Hz3N9_nPRwEDae6yn70M9n47v9ateDlm7zWZtzJbI_GPyA8lJQ7M</recordid><startdate>20090916</startdate><enddate>20090916</enddate><creator>GABOR SZENASI</creator><creator>LASZLO GABOR HARSING</creator><creator>GYULA SIMIG</creator><creator>NORA SZIRAY</creator><creator>ENDRENE FLORIAN</creator><creator>ISTVAN GACSALYI</creator><creator>RITA KAPILLERNE DEZSOFI</creator><creator>KRISZTINA MORICZ</creator><creator>BALAZS VOLK</creator><creator>KATALIN PALLAGI</creator><creator>TIBOR MEZEI</creator><creator>ANDRAS EGYED</creator><creator>JOZSEF BARKOCZY</creator><creator>CSILLA LEVELEKI</creator><creator>GYOERGY LEVAY</creator><creator>GABOR GIGLER</creator><scope>EVB</scope></search><sort><creationdate>20090916</creationdate><title>3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS</title><author>GABOR SZENASI ; 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R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | 3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS |
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