THIADIAZOLIDINONES AS GSK-3 INHIBITORS

Provided arc thiadiazolidinc compounds of formula I wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3...

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Hauptverfasser:	GEMA PANIZODEL PLIEGO, MARIA JOSE PEREZ PUERTO, MIGUEL MEDINA PADILLA, ISABEL DORRONSORO DIAZ, MERCEDES ALONSO CASCON, ANA FUERTES HUERTA, GIL MARTINEZ
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Sprache:	eng ; por
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	GEMA PANIZODEL PLIEGO MARIA JOSE PEREZ PUERTO MIGUEL MEDINA PADILLA ISABEL DORRONSORO DIAZ MERCEDES ALONSO CASCON ANA FUERTES HUERTA GIL MARTINEZ
description	Provided arc thiadiazolidinc compounds of formula I wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	THIADIAZOLIDINONES AS GSK-3 INHIBITORS
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