PROCESSO DE MOAGEM PARA A PRODUCAO DE SUBSTANCIAS MEDICINAIS FINAMENTE MOIDAS

The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine me...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ANDREW B. BROWN, N. MURTI VEMURI, JEAN-RENE AUTHELIN, PATRICK HOSEK
Format:	Patent
Sprache:	por
Schlagworte:	CRUSHING, PULVERISING, OR DISINTEGRATING CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE MILLING GRAIN PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PREPARATORY TREATMENT OF GRAIN FOR MILLING SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.