NOVOS DERIVADOS DE CEFALOTAXANOS E PROCESSO PARA A SUA PREPARACAO
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor whi...
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| creator | CHAUVIAT, LUDOVIC POUTOT, SANDRINE CHARBONNEL, SANDRA GIRODIER, LAURENT GILET, CHRYSTELLE DUJARDIN, GILLES ROBIN, JULIE JEAN-PIERRE ROBIN ROUAUD, SYLVIE ROBERT DHAL CAVOLEAU, SYLVIE MEVELEC, LAURENCE FOURNIER, FLORENCE |
| description | The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%. |
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This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.</description><edition>7</edition><language>por</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050531&DB=EPODOC&CC=PT&NR=1064285E$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050531&DB=EPODOC&CC=PT&NR=1064285E$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHAUVIAT, LUDOVIC</creatorcontrib><creatorcontrib>POUTOT, SANDRINE</creatorcontrib><creatorcontrib>CHARBONNEL, SANDRA</creatorcontrib><creatorcontrib>GIRODIER, LAURENT</creatorcontrib><creatorcontrib>GILET, CHRYSTELLE</creatorcontrib><creatorcontrib>DUJARDIN, GILLES</creatorcontrib><creatorcontrib>ROBIN, JULIE</creatorcontrib><creatorcontrib>JEAN-PIERRE ROBIN</creatorcontrib><creatorcontrib>ROUAUD, SYLVIE</creatorcontrib><creatorcontrib>ROBERT DHAL</creatorcontrib><creatorcontrib>CAVOLEAU, SYLVIE</creatorcontrib><creatorcontrib>MEVELEC, LAURENCE</creatorcontrib><creatorcontrib>FOURNIER, FLORENCE</creatorcontrib><title>NOVOS DERIVADOS DE CEFALOTAXANOS E PROCESSO PARA A SUA PREPARACAO</title><description>The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. 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The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD08w_zD1ZwcQ3yDHN0AbMUnF3dHH38QxwjgJLBCq4KAUH-zq7Bwf4KAY5BjgqOCsGhjkAxVxDP2dGfh4E1LTGnOJUXSnMzKLi5hjh76KYW5MenFhckJqfmpZbEB4QYGpiZGFmYuroaE6EEAHPfKpg</recordid><startdate>20050531</startdate><enddate>20050531</enddate><creator>CHAUVIAT, LUDOVIC</creator><creator>POUTOT, SANDRINE</creator><creator>CHARBONNEL, SANDRA</creator><creator>GIRODIER, LAURENT</creator><creator>GILET, CHRYSTELLE</creator><creator>DUJARDIN, GILLES</creator><creator>ROBIN, JULIE</creator><creator>JEAN-PIERRE ROBIN</creator><creator>ROUAUD, SYLVIE</creator><creator>ROBERT DHAL</creator><creator>CAVOLEAU, SYLVIE</creator><creator>MEVELEC, LAURENCE</creator><creator>FOURNIER, FLORENCE</creator><scope>EVB</scope></search><sort><creationdate>20050531</creationdate><title>NOVOS DERIVADOS DE CEFALOTAXANOS E PROCESSO PARA A SUA PREPARACAO</title><author>CHAUVIAT, LUDOVIC ; POUTOT, SANDRINE ; CHARBONNEL, SANDRA ; GIRODIER, LAURENT ; GILET, CHRYSTELLE ; DUJARDIN, GILLES ; ROBIN, JULIE ; JEAN-PIERRE ROBIN ; ROUAUD, SYLVIE ; ROBERT DHAL ; CAVOLEAU, SYLVIE ; MEVELEC, LAURENCE ; FOURNIER, FLORENCE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PT1064285EE3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>por</language><creationdate>2005</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHAUVIAT, LUDOVIC</creatorcontrib><creatorcontrib>POUTOT, SANDRINE</creatorcontrib><creatorcontrib>CHARBONNEL, SANDRA</creatorcontrib><creatorcontrib>GIRODIER, LAURENT</creatorcontrib><creatorcontrib>GILET, CHRYSTELLE</creatorcontrib><creatorcontrib>DUJARDIN, GILLES</creatorcontrib><creatorcontrib>ROBIN, JULIE</creatorcontrib><creatorcontrib>JEAN-PIERRE ROBIN</creatorcontrib><creatorcontrib>ROUAUD, SYLVIE</creatorcontrib><creatorcontrib>ROBERT DHAL</creatorcontrib><creatorcontrib>CAVOLEAU, SYLVIE</creatorcontrib><creatorcontrib>MEVELEC, LAURENCE</creatorcontrib><creatorcontrib>FOURNIER, FLORENCE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHAUVIAT, LUDOVIC</au><au>POUTOT, SANDRINE</au><au>CHARBONNEL, SANDRA</au><au>GIRODIER, LAURENT</au><au>GILET, CHRYSTELLE</au><au>DUJARDIN, GILLES</au><au>ROBIN, JULIE</au><au>JEAN-PIERRE ROBIN</au><au>ROUAUD, SYLVIE</au><au>ROBERT DHAL</au><au>CAVOLEAU, SYLVIE</au><au>MEVELEC, LAURENCE</au><au>FOURNIER, FLORENCE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVOS DERIVADOS DE CEFALOTAXANOS E PROCESSO PARA A SUA PREPARACAO</title><date>2005-05-31</date><risdate>2005</risdate><abstract>The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVOS DERIVADOS DE CEFALOTAXANOS E PROCESSO PARA A SUA PREPARACAO |
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