PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF ATR KINASE FOR THE TREATMENT OF CANCER DISEASES
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this inv...
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| creator | AHMAD, NADIA KNEGTEL, ROLAND DAVIS, REBECCA DURRANT, STEVEN STUDLEY, JOHN CHARRIER, JEAN-DAMIEN ETXEBARRIA I JARDI, GORKA KAY, DAVID DAVIS, CHRIS PINDER, JOANNE SHAW, DAVID JIMENEZ, JUAN-MIGUEL PANESAR, MANINDER PIERARD, FRANCOISE FRAYSSE, DAMINE MIDDLETON, DONALD ODONNELL, MICHAEL TWIN, HEATHER STORCK, PIERRE-HENRI BOYALL, DEAN |
| description | The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein. |
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The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.</description><language>eng ; pol</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230710&DB=EPODOC&CC=PL&NR=3808749T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230710&DB=EPODOC&CC=PL&NR=3808749T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AHMAD, NADIA</creatorcontrib><creatorcontrib>KNEGTEL, ROLAND</creatorcontrib><creatorcontrib>DAVIS, REBECCA</creatorcontrib><creatorcontrib>DURRANT, STEVEN</creatorcontrib><creatorcontrib>STUDLEY, JOHN</creatorcontrib><creatorcontrib>CHARRIER, JEAN-DAMIEN</creatorcontrib><creatorcontrib>ETXEBARRIA I JARDI, GORKA</creatorcontrib><creatorcontrib>KAY, DAVID</creatorcontrib><creatorcontrib>DAVIS, CHRIS</creatorcontrib><creatorcontrib>PINDER, JOANNE</creatorcontrib><creatorcontrib>SHAW, DAVID</creatorcontrib><creatorcontrib>JIMENEZ, JUAN-MIGUEL</creatorcontrib><creatorcontrib>PANESAR, MANINDER</creatorcontrib><creatorcontrib>PIERARD, FRANCOISE</creatorcontrib><creatorcontrib>FRAYSSE, DAMINE</creatorcontrib><creatorcontrib>MIDDLETON, DONALD</creatorcontrib><creatorcontrib>ODONNELL, MICHAEL</creatorcontrib><creatorcontrib>TWIN, HEATHER</creatorcontrib><creatorcontrib>STORCK, PIERRE-HENRI</creatorcontrib><creatorcontrib>BOYALL, DEAN</creatorcontrib><title>PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF ATR KINASE FOR THE TREATMENT OF CANCER DISEASES</title><description>The present invention relates to compounds useful as inhibitors of ATR protein kinase. 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The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS INHIBITORS OF ATR KINASE FOR THE TREATMENT OF CANCER DISEASES |
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