MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
The invention discloses compounds of Formula (I):wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production...
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| creator | PICOLET, OLIVIER LAURENT KYM, PHILIP R MERAYO MERAYO, NURIA MALAGU, KARINE FABIENNE VAN DER PLAS, STEVEN EMIEL PIZZONERO, MATHIEU RAFAËL COUTY, SYLVAIN YEUNG, MING C DESROY, NICOLAS MAI, THI THU TRANG SEARLE, XENIA B GFESSER, GREGORY A HOUSSEMAN, CHRISTOPHER GAËTAN WANG, XUEQING ALTENBACH, ROBERT J BOGDAN, ANDREW LIU, BO |
| description | The invention discloses compounds of Formula (I):wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production and methods of treating cystic fibrosis by administering the compounds. |
| format | Patent |
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The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. 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The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production and methods of treating cystic fibrosis by administering the compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE |
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