CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF
The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds...
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| creator | GROOM COLIN ROGER HOPKINS ANDREW LEE O'GARA MARGARET MARY RINGROSE HEATHER JOAN BROWN DAVID GRAHAM JENKINS TIMOTHY MARK ROBINSON COLIN MARK TAYLOR WENDY ELAINE KAMP SARAH HELEN |
| description | The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by the present invention are crystals of PDE5/PDE5 inhibitor complexes. |
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The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by the present invention are crystals of PDE5/PDE5 inhibitor complexes.</description><edition>7</edition><language>eng ; pol</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050530&DB=EPODOC&CC=PL&NR=370513A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050530&DB=EPODOC&CC=PL&NR=370513A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GROOM COLIN ROGER</creatorcontrib><creatorcontrib>HOPKINS ANDREW LEE</creatorcontrib><creatorcontrib>O'GARA MARGARET MARY</creatorcontrib><creatorcontrib>RINGROSE HEATHER JOAN</creatorcontrib><creatorcontrib>BROWN DAVID GRAHAM</creatorcontrib><creatorcontrib>JENKINS TIMOTHY MARK</creatorcontrib><creatorcontrib>ROBINSON COLIN MARK</creatorcontrib><creatorcontrib>TAYLOR WENDY ELAINE</creatorcontrib><creatorcontrib>KAMP SARAH HELEN</creatorcontrib><title>CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF</title><description>The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. 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Also contemplated by the present invention are crystals of PDE5/PDE5 inhibitor complexes.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBwDooMDnH0UQgOCQp1DgkNclXwd1MI8PAPBmIXT9fgENcgx2BXBVMFRz8XhVAgK8TDNcjV342HgTUtMac4lRdKczPIu7mGOHvophbkx6cWFyQmp-allsQH-BibG5gaGjsaGhNWAQDhlifN</recordid><startdate>20050530</startdate><enddate>20050530</enddate><creator>GROOM COLIN ROGER</creator><creator>HOPKINS ANDREW LEE</creator><creator>O'GARA MARGARET MARY</creator><creator>RINGROSE HEATHER JOAN</creator><creator>BROWN DAVID GRAHAM</creator><creator>JENKINS TIMOTHY MARK</creator><creator>ROBINSON COLIN MARK</creator><creator>TAYLOR WENDY ELAINE</creator><creator>KAMP SARAH HELEN</creator><scope>EVB</scope></search><sort><creationdate>20050530</creationdate><title>CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF</title><author>GROOM COLIN ROGER ; HOPKINS ANDREW LEE ; O'GARA MARGARET MARY ; RINGROSE HEATHER JOAN ; BROWN DAVID GRAHAM ; JENKINS TIMOTHY MARK ; ROBINSON COLIN MARK ; TAYLOR WENDY ELAINE ; KAMP SARAH HELEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL370513A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2005</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GROOM COLIN ROGER</creatorcontrib><creatorcontrib>HOPKINS ANDREW LEE</creatorcontrib><creatorcontrib>O'GARA MARGARET MARY</creatorcontrib><creatorcontrib>RINGROSE HEATHER JOAN</creatorcontrib><creatorcontrib>BROWN DAVID GRAHAM</creatorcontrib><creatorcontrib>JENKINS TIMOTHY MARK</creatorcontrib><creatorcontrib>ROBINSON COLIN MARK</creatorcontrib><creatorcontrib>TAYLOR WENDY ELAINE</creatorcontrib><creatorcontrib>KAMP SARAH HELEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GROOM COLIN ROGER</au><au>HOPKINS ANDREW LEE</au><au>O'GARA MARGARET MARY</au><au>RINGROSE HEATHER JOAN</au><au>BROWN DAVID GRAHAM</au><au>JENKINS TIMOTHY MARK</au><au>ROBINSON COLIN MARK</au><au>TAYLOR WENDY ELAINE</au><au>KAMP SARAH HELEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF</title><date>2005-05-30</date><risdate>2005</risdate><abstract>The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by the present invention are crystals of PDE5/PDE5 inhibitor complexes.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF |
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