2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS
The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; pol |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CLARK KENNETH LYLE HARRIS NEIL VICTOR ALEY AMANDA ARCHER JANET ANN COLEMAN ROBERT ALEXANDER BORMAN RICHARD ANTHONY OXFORD ALEXANDER WILLIAM HYND GEORGE |
| description | The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PL370221A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PL370221A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PL370221A13</originalsourceid><addsrcrecordid>eNrjZLA20vWPcIzy93H09fRzDVZw9HNRCPFw9QxSCA12VXAMVjDV9QgxclIIcnV2DQjxDwIqCHF09_fzDA4J5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8QE-xuYGRkaGjobGhFUAABBzKB4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS</title><source>esp@cenet</source><creator>CLARK KENNETH LYLE ; HARRIS NEIL VICTOR ; ALEY AMANDA ; ARCHER JANET ANN ; COLEMAN ROBERT ALEXANDER ; BORMAN RICHARD ANTHONY ; OXFORD ALEXANDER WILLIAM ; HYND GEORGE</creator><creatorcontrib>CLARK KENNETH LYLE ; HARRIS NEIL VICTOR ; ALEY AMANDA ; ARCHER JANET ANN ; COLEMAN ROBERT ALEXANDER ; BORMAN RICHARD ANTHONY ; OXFORD ALEXANDER WILLIAM ; HYND GEORGE</creatorcontrib><description>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><edition>7</edition><language>eng ; pol</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050516&DB=EPODOC&CC=PL&NR=370221A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050516&DB=EPODOC&CC=PL&NR=370221A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CLARK KENNETH LYLE</creatorcontrib><creatorcontrib>HARRIS NEIL VICTOR</creatorcontrib><creatorcontrib>ALEY AMANDA</creatorcontrib><creatorcontrib>ARCHER JANET ANN</creatorcontrib><creatorcontrib>COLEMAN ROBERT ALEXANDER</creatorcontrib><creatorcontrib>BORMAN RICHARD ANTHONY</creatorcontrib><creatorcontrib>OXFORD ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>HYND GEORGE</creatorcontrib><title>2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS</title><description>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLA20vWPcIzy93H09fRzDVZw9HNRCPFw9QxSCA12VXAMVjDV9QgxclIIcnV2DQjxDwIqCHF09_fzDA4J5mFgTUvMKU7lhdLcDPJuriHOHrqpBfnxqcUFicmpeakl8QE-xuYGRkaGjobGhFUAABBzKB4</recordid><startdate>20050516</startdate><enddate>20050516</enddate><creator>CLARK KENNETH LYLE</creator><creator>HARRIS NEIL VICTOR</creator><creator>ALEY AMANDA</creator><creator>ARCHER JANET ANN</creator><creator>COLEMAN ROBERT ALEXANDER</creator><creator>BORMAN RICHARD ANTHONY</creator><creator>OXFORD ALEXANDER WILLIAM</creator><creator>HYND GEORGE</creator><scope>EVB</scope></search><sort><creationdate>20050516</creationdate><title>2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS</title><author>CLARK KENNETH LYLE ; HARRIS NEIL VICTOR ; ALEY AMANDA ; ARCHER JANET ANN ; COLEMAN ROBERT ALEXANDER ; BORMAN RICHARD ANTHONY ; OXFORD ALEXANDER WILLIAM ; HYND GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL370221A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CLARK KENNETH LYLE</creatorcontrib><creatorcontrib>HARRIS NEIL VICTOR</creatorcontrib><creatorcontrib>ALEY AMANDA</creatorcontrib><creatorcontrib>ARCHER JANET ANN</creatorcontrib><creatorcontrib>COLEMAN ROBERT ALEXANDER</creatorcontrib><creatorcontrib>BORMAN RICHARD ANTHONY</creatorcontrib><creatorcontrib>OXFORD ALEXANDER WILLIAM</creatorcontrib><creatorcontrib>HYND GEORGE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CLARK KENNETH LYLE</au><au>HARRIS NEIL VICTOR</au><au>ALEY AMANDA</au><au>ARCHER JANET ANN</au><au>COLEMAN ROBERT ALEXANDER</au><au>BORMAN RICHARD ANTHONY</au><au>OXFORD ALEXANDER WILLIAM</au><au>HYND GEORGE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS</title><date>2005-05-16</date><risdate>2005</risdate><abstract>The present invention relates to compounds of formula I: wherein one of R1 and R4 is selected from the group consisting of H, and optionally substituted C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, and phenyl-C1-4 alkyl; and the other of R1 and R4 is an optionally substituted C9-14 aryl group; R2 and R3 are either: (i) independently selected from H, R, R', SO2R, C(-O)R, (CH2)nNR5R6, where n is from 1 to 4 and R5 and R6 are independently selected from H and R, where R is optionally substituted C1-4 alkyl, and R' is optionally substituted phenyl-C1-4 alkyl, or (ii) together with the nitrogen atom to which they are attached, form an optionally substituted C5-7 heterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HT2B receptor.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; pol |
| recordid | cdi_epo_espacenet_PL370221A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A22%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CLARK%20KENNETH%20LYLE&rft.date=2005-05-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EPL370221A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |