PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES

PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES

The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R and R independently each stands for C1-4-alkyl or together form C2-6-alkyle...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GREFF ZOLTAN, VAGO PAL, MOLNARNE SAMU ERIKA, SIMIG GYULA
Format: Patent
Sprache:eng ; pol
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator GREFF ZOLTAN
VAGO PAL
MOLNARNE SAMU ERIKA
SIMIG GYULA
description The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R and R independently each stands for C1-4-alkyl or together form C2-6-alkylene) with hydrazine or a hydrate or salt thereof formed with an inorganic or organic acid. 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of the Formula I is a known anxiolytic agent. The invention also relates to new intermediates and a process for the preparation thereof.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PL370036A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PL370036A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PL370036A13</originalsourceid><addsrcrecordid>eNrjZLALCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCPF38wz2D3D0VXD0c1Hwcw1X8PQLcQ3ydXXxdAxxDeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfEBPsbmBgbGZo6GxoRVAAC8Ayld</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES</title><source>esp@cenet</source><creator>GREFF ZOLTAN ; VAGO PAL ; MOLNARNE SAMU ERIKA ; SIMIG GYULA</creator><creatorcontrib>GREFF ZOLTAN ; VAGO PAL ; MOLNARNE SAMU ERIKA ; SIMIG GYULA</creatorcontrib><description>The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R and R independently each stands for C1-4-alkyl or together form C2-6-alkylene) with hydrazine or a hydrate or salt thereof formed with an inorganic or organic acid. 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of the Formula I is a known anxiolytic agent. The invention also relates to new intermediates and a process for the preparation thereof.</description><edition>7</edition><language>eng ; pol</language><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20050516&amp;DB=EPODOC&amp;CC=PL&amp;NR=370036A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20050516&amp;DB=EPODOC&amp;CC=PL&amp;NR=370036A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GREFF ZOLTAN</creatorcontrib><creatorcontrib>VAGO PAL</creatorcontrib><creatorcontrib>MOLNARNE SAMU ERIKA</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><title>PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES</title><description>The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R and R independently each stands for C1-4-alkyl or together form C2-6-alkylene) with hydrazine or a hydrate or salt thereof formed with an inorganic or organic acid. 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of the Formula I is a known anxiolytic agent. The invention also relates to new intermediates and a process for the preparation thereof.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCPF38wz2D3D0VXD0c1Hwcw1X8PQLcQ3ydXXxdAxxDeZhYE1LzClO5YXS3Azybq4hzh66qQX58anFBYnJqXmpJfEBPsbmBgbGZo6GxoRVAAC8Ayld</recordid><startdate>20050516</startdate><enddate>20050516</enddate><creator>GREFF ZOLTAN</creator><creator>VAGO PAL</creator><creator>MOLNARNE SAMU ERIKA</creator><creator>SIMIG GYULA</creator><scope>EVB</scope></search><sort><creationdate>20050516</creationdate><title>PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES</title><author>GREFF ZOLTAN ; VAGO PAL ; MOLNARNE SAMU ERIKA ; SIMIG GYULA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL370036A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2005</creationdate><toplevel>online_resources</toplevel><creatorcontrib>GREFF ZOLTAN</creatorcontrib><creatorcontrib>VAGO PAL</creatorcontrib><creatorcontrib>MOLNARNE SAMU ERIKA</creatorcontrib><creatorcontrib>SIMIG GYULA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GREFF ZOLTAN</au><au>VAGO PAL</au><au>MOLNARNE SAMU ERIKA</au><au>SIMIG GYULA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES</title><date>2005-05-16</date><risdate>2005</risdate><abstract>The invention relates to a new process for the preparation of 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodizepine of Formula (I) which comprises reacting a compound of general Formula (II) (wherein R and R independently each stands for C1-4-alkyl or together form C2-6-alkylene) with hydrazine or a hydrate or salt thereof formed with an inorganic or organic acid. 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of the Formula I is a known anxiolytic agent. The invention also relates to new intermediates and a process for the preparation thereof.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; pol
recordid cdi_epo_espacenet_PL370036A1
source esp@cenet
title PROCESS FOR THE PREPARATION OF TOFISOPAM AND NEW INTERMEDIATES
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T19%3A11%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GREFF%20ZOLTAN&rft.date=2005-05-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EPL370036A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true