PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES
Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes...
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| creator | WANG SHELDON GIRANDA VINCENT L SHAM HING L XU YIBO MUCHMORE STEVEN W ZHAO CHEN MADIGAN DAROLD L DEGOEY DAVID A KATI WARREN M STOLL VINCENT S CHEN YUANWEI KENNEDY APRIL MARING CLARENCE J SUN MINGHUA WANG GARY T GU YU-GUI GRAMPOVNIK DAVID J KLEIN LARRY L LIN ZHEN FLOSI WILLIAM J KRUEGER ALLAN C MCDANIEL KEITH F YEUNG MING C KEMPF DALE J CHEN HUI-JU STEWART KENT D |
| description | Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes. |
| format | Patent |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES |
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