NOVEL DERIVATIVES OF 1,7,7-TRIMETHYL-BICYCLO[2.2.1]HEPTANE
1. A compound with formula (I) and its pharmaceutically permissible addition salt with non-organic or organic acid. 4. A method of producing the compound with formula (I) determined in claim L, and of its pharmaceutically permissible addition salt with acid. It is characterised in that it involves (...
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creator | SCHMIDT EVA BLASKO GABOR GREZAL GYULA GACSALYI ISTVAN BILKEI GORZO ANDRAS ABERMANN MIKLOS BALOGHNE NEMES KATALIN EGYED ANDRAS GYERTYAN ISTVAN KLEBOVICH IMRE BUDAI ZOLTAN KAUFMANNE BOJTI ERZSEBET LUKACS GYULA |
description | 1. A compound with formula (I) and its pharmaceutically permissible addition salt with non-organic or organic acid. 4. A method of producing the compound with formula (I) determined in claim L, and of its pharmaceutically permissible addition salt with acid. It is characterised in that it involves (a) monodemethylation of the compound with formula (II) by reacting it with the compound with generalised formula (IV) in which R1> is C1-4-alkyl group, phenyl group or naphthyl group and Hlg stands for a halogen; further, the compound with generalised formula (V) produced in such a manner, in which R1> is specified above, is reacted with a base, or (b) removing, by hydrogenation, of a catalytically covering benzyl group, from the compound with generalised formula (III) in which R stands for a benzyl group; and, if needed, the separation of the racemic compound (I) produced in such a manner into optically active isomers, preferably through the fractional crystallisation or through the application of the chromatographic separation, preferably in a chiral column; and, if needed, transforming the compound with the formula (I) into a pharmaceutically permissible addition salt with acid or releasing a base from its salt. 8. Pharmaceutical composition which contains neutral solid or liquid carriers or assistant agents. It is characterised in that that as an active agent, it contains the compound with the formula (I) or its pharmaceutically permissible addition salt with non-organic or organic acid. |
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A compound with formula (I) and its pharmaceutically permissible addition salt with non-organic or organic acid. 4. A method of producing the compound with formula (I) determined in claim L, and of its pharmaceutically permissible addition salt with acid. It is characterised in that it involves (a) monodemethylation of the compound with formula (II) by reacting it with the compound with generalised formula (IV) in which R1> is C1-4-alkyl group, phenyl group or naphthyl group and Hlg stands for a halogen; further, the compound with generalised formula (V) produced in such a manner, in which R1> is specified above, is reacted with a base, or (b) removing, by hydrogenation, of a catalytically covering benzyl group, from the compound with generalised formula (III) in which R stands for a benzyl group; and, if needed, the separation of the racemic compound (I) produced in such a manner into optically active isomers, preferably through the fractional crystallisation or through the application of the chromatographic separation, preferably in a chiral column; and, if needed, transforming the compound with the formula (I) into a pharmaceutically permissible addition salt with acid or releasing a base from its salt. 8. Pharmaceutical composition which contains neutral solid or liquid carriers or assistant agents. 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A compound with formula (I) and its pharmaceutically permissible addition salt with non-organic or organic acid. 4. A method of producing the compound with formula (I) determined in claim L, and of its pharmaceutically permissible addition salt with acid. It is characterised in that it involves (a) monodemethylation of the compound with formula (II) by reacting it with the compound with generalised formula (IV) in which R1> is C1-4-alkyl group, phenyl group or naphthyl group and Hlg stands for a halogen; further, the compound with generalised formula (V) produced in such a manner, in which R1> is specified above, is reacted with a base, or (b) removing, by hydrogenation, of a catalytically covering benzyl group, from the compound with generalised formula (III) in which R stands for a benzyl group; and, if needed, the separation of the racemic compound (I) produced in such a manner into optically active isomers, preferably through the fractional crystallisation or through the application of the chromatographic separation, preferably in a chiral column; and, if needed, transforming the compound with the formula (I) into a pharmaceutically permissible addition salt with acid or releasing a base from its salt. 8. Pharmaceutical composition which contains neutral solid or liquid carriers or assistant agents. 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A compound with formula (I) and its pharmaceutically permissible addition salt with non-organic or organic acid. 4. A method of producing the compound with formula (I) determined in claim L, and of its pharmaceutically permissible addition salt with acid. It is characterised in that it involves (a) monodemethylation of the compound with formula (II) by reacting it with the compound with generalised formula (IV) in which R1> is C1-4-alkyl group, phenyl group or naphthyl group and Hlg stands for a halogen; further, the compound with generalised formula (V) produced in such a manner, in which R1> is specified above, is reacted with a base, or (b) removing, by hydrogenation, of a catalytically covering benzyl group, from the compound with generalised formula (III) in which R stands for a benzyl group; and, if needed, the separation of the racemic compound (I) produced in such a manner into optically active isomers, preferably through the fractional crystallisation or through the application of the chromatographic separation, preferably in a chiral column; and, if needed, transforming the compound with the formula (I) into a pharmaceutically permissible addition salt with acid or releasing a base from its salt. 8. Pharmaceutical composition which contains neutral solid or liquid carriers or assistant agents. It is characterised in that that as an active agent, it contains the compound with the formula (I) or its pharmaceutically permissible addition salt with non-organic or organic acid.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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title | NOVEL DERIVATIVES OF 1,7,7-TRIMETHYL-BICYCLO[2.2.1]HEPTANE |
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