IL-18 BINDING MOLECULES
IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 recepto...
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| creator | KUNZ, CHRISTIAN CARSTEN SILVESTER CAMPBELL, EMMA MICHELLE DIEFENBACH-STREIBER, BEATE BRANNETTI, BARBARA VAN HEEKE, GINO ANSELMUS RONDEAU, JEAN-MICHEL RENE BARDROFF, MICHAEL OTTO EBERTH, ADINA SCHLAEPPI, JEAN-MARC ALFRED MARSHALL, SYLWIA |
| description | IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool. |
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The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.</description><language>eng ; pol</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200907&DB=EPODOC&CC=PL&NR=2892923T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200907&DB=EPODOC&CC=PL&NR=2892923T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUNZ, CHRISTIAN CARSTEN SILVESTER</creatorcontrib><creatorcontrib>CAMPBELL, EMMA MICHELLE</creatorcontrib><creatorcontrib>DIEFENBACH-STREIBER, BEATE</creatorcontrib><creatorcontrib>BRANNETTI, BARBARA</creatorcontrib><creatorcontrib>VAN HEEKE, GINO ANSELMUS</creatorcontrib><creatorcontrib>RONDEAU, JEAN-MICHEL RENE</creatorcontrib><creatorcontrib>BARDROFF, MICHAEL OTTO</creatorcontrib><creatorcontrib>EBERTH, ADINA</creatorcontrib><creatorcontrib>SCHLAEPPI, JEAN-MARC ALFRED</creatorcontrib><creatorcontrib>MARSHALL, SYLWIA</creatorcontrib><title>IL-18 BINDING MOLECULES</title><description>IL-18 participates in both innate and acquired immunity. 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The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD39NE1tFBw8vRz8fRzV_D193F1DvVxDeZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfEBPkYWlkaWRsYhIcbGxKgBALmtH50</recordid><startdate>20200907</startdate><enddate>20200907</enddate><creator>KUNZ, CHRISTIAN CARSTEN SILVESTER</creator><creator>CAMPBELL, EMMA MICHELLE</creator><creator>DIEFENBACH-STREIBER, BEATE</creator><creator>BRANNETTI, BARBARA</creator><creator>VAN HEEKE, GINO ANSELMUS</creator><creator>RONDEAU, JEAN-MICHEL RENE</creator><creator>BARDROFF, MICHAEL OTTO</creator><creator>EBERTH, ADINA</creator><creator>SCHLAEPPI, JEAN-MARC ALFRED</creator><creator>MARSHALL, SYLWIA</creator><scope>EVB</scope></search><sort><creationdate>20200907</creationdate><title>IL-18 BINDING MOLECULES</title><author>KUNZ, CHRISTIAN CARSTEN SILVESTER ; CAMPBELL, EMMA MICHELLE ; DIEFENBACH-STREIBER, BEATE ; BRANNETTI, BARBARA ; VAN HEEKE, GINO ANSELMUS ; RONDEAU, JEAN-MICHEL RENE ; BARDROFF, MICHAEL OTTO ; EBERTH, ADINA ; SCHLAEPPI, JEAN-MARC ALFRED ; MARSHALL, SYLWIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL2892923TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>KUNZ, CHRISTIAN CARSTEN SILVESTER</creatorcontrib><creatorcontrib>CAMPBELL, EMMA MICHELLE</creatorcontrib><creatorcontrib>DIEFENBACH-STREIBER, BEATE</creatorcontrib><creatorcontrib>BRANNETTI, BARBARA</creatorcontrib><creatorcontrib>VAN HEEKE, GINO ANSELMUS</creatorcontrib><creatorcontrib>RONDEAU, JEAN-MICHEL RENE</creatorcontrib><creatorcontrib>BARDROFF, MICHAEL OTTO</creatorcontrib><creatorcontrib>EBERTH, ADINA</creatorcontrib><creatorcontrib>SCHLAEPPI, JEAN-MARC ALFRED</creatorcontrib><creatorcontrib>MARSHALL, SYLWIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUNZ, CHRISTIAN CARSTEN SILVESTER</au><au>CAMPBELL, EMMA MICHELLE</au><au>DIEFENBACH-STREIBER, BEATE</au><au>BRANNETTI, BARBARA</au><au>VAN HEEKE, GINO ANSELMUS</au><au>RONDEAU, JEAN-MICHEL RENE</au><au>BARDROFF, MICHAEL OTTO</au><au>EBERTH, ADINA</au><au>SCHLAEPPI, JEAN-MARC ALFRED</au><au>MARSHALL, SYLWIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IL-18 BINDING MOLECULES</title><date>2020-09-07</date><risdate>2020</risdate><abstract>IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally occurring and highly specific inhibitor. This soluble protein forms a complex with free IL-18 preventing its interaction with the IL-18 receptor, thus neutralizing and inhibiting its biological activity. The present invention discloses binding molecules, in particular antibodies or fragments thereof, which bind IL-18 and do not bind IL-18 bound to IL-18BP (IL-18/IL-18BP complex). Apart from its physiological role, IL-18 has been shown to mediate a variety of autoimmune and inflammatory diseases. The binding molecules of the inventions may be used as therapeutic molecules for treating IL-18-related autoimmune and inflammatory diseases or as diagnostic tools for characterizing, detecting and/or measuring IL-18 not bound to IL-18BP as component of the total IL-18 pool.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING |
| title | IL-18 BINDING MOLECULES |
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