METHOD OF PREPARING SITAGLIPTIN

METHOD OF PREPARING SITAGLIPTIN

The solution relates to a method of preparing sitagliptin of formula I, comprising hydrogenation of an enamino-amide precursor of formula II, wherein the hydrogenation is carried out in a suspension or a solution and is catalyzed by a complex compound formed of Ru and an (R) or (S)-pseudo-o-bisphosp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JIRMAN, JOSEF, RICHTER, JINDRICH
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The solution relates to a method of preparing sitagliptin of formula I, comprising hydrogenation of an enamino-amide precursor of formula II, wherein the hydrogenation is carried out in a suspension or a solution and is catalyzed by a complex compound formed of Ru and an (R) or (S)-pseudo-o-bisphosphino-[2,2]-paracyclophane ligand of general formula VI, wherein R are the same or different substituents from the group consisting of C1-4 alkyls, C3-8 cycloalkyls and Ar, and Ar is an unsubstituted or substituted aryl, and optionally other component(s) necessary for formation of the complex compound.