N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS

N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

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Bibliographische Detailangaben
Hauptverfasser: MILLER, WILLIAM HENRY, ZIMMERMAN, MICHAEL N, SHAW, ANTONY N, DUFFY, KEVIN J, MYERS, ANDREA K
Format: Patent
Sprache:eng ; pol
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.