NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID
Producing steroidal amines (I) with an alpha or beta primary amino group in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17 comprises treating the corresponding oxime (II) with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. Producing steroid...
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| creator | SIMONNET, ANDRÉ BOUSQUET-FRANCES, JOËLLE CAZENAVE, GÉRARD ODDON, GILLES BERNARD, DANIEL |
| description | Producing steroidal amines (I) with an alpha or beta primary amino group in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17 comprises treating the corresponding oxime (II) with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. Producing steroidal amines of formula (I) comprises treating an oxime of formula (II) oxime with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. St-NH 2 (I) St=NOR (II) St : an optionally substituted steroid residue bonded to NH 2 or NOR in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17, with NH 2 in the alpha or beta configuration; R : H, 1-12C (cyclo)alkyl, 6-12C aryl or 7-12C aralkyl. |
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Producing steroidal amines of formula (I) comprises treating an oxime of formula (II) oxime with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. St-NH 2 (I) St=NOR (II) St : an optionally substituted steroid residue bonded to NH 2 or NOR in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17, with NH 2 in the alpha or beta configuration; R : H, 1-12C (cyclo)alkyl, 6-12C aryl or 7-12C aralkyl.</description><language>eng ; pol</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; STEROIDS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111230&DB=EPODOC&CC=PL&NR=2121724T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111230&DB=EPODOC&CC=PL&NR=2121724T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIMONNET, ANDRÉ</creatorcontrib><creatorcontrib>BOUSQUET-FRANCES, JOËLLE</creatorcontrib><creatorcontrib>CAZENAVE, GÉRARD</creatorcontrib><creatorcontrib>ODDON, GILLES</creatorcontrib><creatorcontrib>BERNARD, DANIEL</creatorcontrib><title>NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID</title><description>Producing steroidal amines (I) with an alpha or beta primary amino group in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17 comprises treating the corresponding oxime (II) with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. Producing steroidal amines of formula (I) comprises treating an oxime of formula (II) oxime with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. St-NH 2 (I) St=NOR (II) St : an optionally substituted steroid residue bonded to NH 2 or NOR in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17, with NH 2 in the alpha or beta configuration; R : H, 1-12C (cyclo)alkyl, 6-12C aryl or 7-12C aralkyl.</description><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbNxIeodxgO4aCq4DsmEBJJMScdCV6VIXIkW6v0xggdw9T_vv78VY6IBA0RkRwYsZWCHYLzqGTNSjwE1-wGhy2SutVICsqBAO59VqNhHlUdQ0SeEOir4Psmbvdjc58daDr_ciaNF1u5UltdU1mW-lWd5T12QjWwu8szctv84HxgDMbc</recordid><startdate>20111230</startdate><enddate>20111230</enddate><creator>SIMONNET, ANDRÉ</creator><creator>BOUSQUET-FRANCES, JOËLLE</creator><creator>CAZENAVE, GÉRARD</creator><creator>ODDON, GILLES</creator><creator>BERNARD, DANIEL</creator><scope>EVB</scope></search><sort><creationdate>20111230</creationdate><title>NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID</title><author>SIMONNET, ANDRÉ ; BOUSQUET-FRANCES, JOËLLE ; CAZENAVE, GÉRARD ; ODDON, GILLES ; BERNARD, DANIEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL2121724TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>SIMONNET, ANDRÉ</creatorcontrib><creatorcontrib>BOUSQUET-FRANCES, JOËLLE</creatorcontrib><creatorcontrib>CAZENAVE, GÉRARD</creatorcontrib><creatorcontrib>ODDON, GILLES</creatorcontrib><creatorcontrib>BERNARD, DANIEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIMONNET, ANDRÉ</au><au>BOUSQUET-FRANCES, JOËLLE</au><au>CAZENAVE, GÉRARD</au><au>ODDON, GILLES</au><au>BERNARD, DANIEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID</title><date>2011-12-30</date><risdate>2011</risdate><abstract>Producing steroidal amines (I) with an alpha or beta primary amino group in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17 comprises treating the corresponding oxime (II) with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. Producing steroidal amines of formula (I) comprises treating an oxime of formula (II) oxime with lithium in liquid ammonia at -33 to -90[deg] C in a solvent comprising an ether and an aliphatic alcohol. St-NH 2 (I) St=NOR (II) St : an optionally substituted steroid residue bonded to NH 2 or NOR in position 1, 2, 3, 4, 6, 7, 11, 12, 15, 16 or 17, with NH 2 in the alpha or beta configuration; R : H, 1-12C (cyclo)alkyl, 6-12C aryl or 7-12C aralkyl.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| title | NOVEL METHOD FOR THE DIASTEREOSELECTIVE PRODUCTION OF A CHIRAL PRIMARY AMINE ON A STEROID |
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