PEPTIDOMIMETIC PROTEASE INHIBITORS
The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. Th...
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| creator | TEBBE MARK JOSEPH WANG Q. MAY COLLADO IVAN BABINE ROBERT EWDARD GUO DEQI LAMAR JASON ERIC SNYDER NANCY JUNE VICTOR FRANTZ YIP YVONNE YEE MAI SUN XICHENG DAVID CHEN SHU HUI PARKER RAYMOND SAMUEL III GLASS JOHN IRVIN JIN LING GARCIA-PAREDES CRISTINA |
| description | The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient. |
| format | Patent |
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MAY ; COLLADO IVAN ; BABINE ROBERT EWDARD ; GUO DEQI ; LAMAR JASON ERIC ; SNYDER NANCY JUNE ; VICTOR FRANTZ ; YIP YVONNE YEE MAI ; SUN XICHENG DAVID ; CHEN SHU HUI ; PARKER RAYMOND SAMUEL III ; GLASS JOHN IRVIN ; JIN LING ; GARCIA-PAREDES CRISTINA</creatorcontrib><description>The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.</description><language>eng ; pol</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120330&DB=EPODOC&CC=PL&NR=211019B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120330&DB=EPODOC&CC=PL&NR=211019B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TEBBE MARK JOSEPH</creatorcontrib><creatorcontrib>WANG Q. 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The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. 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MAY</creatorcontrib><creatorcontrib>COLLADO IVAN</creatorcontrib><creatorcontrib>BABINE ROBERT EWDARD</creatorcontrib><creatorcontrib>GUO DEQI</creatorcontrib><creatorcontrib>LAMAR JASON ERIC</creatorcontrib><creatorcontrib>SNYDER NANCY JUNE</creatorcontrib><creatorcontrib>VICTOR FRANTZ</creatorcontrib><creatorcontrib>YIP YVONNE YEE MAI</creatorcontrib><creatorcontrib>SUN XICHENG DAVID</creatorcontrib><creatorcontrib>CHEN SHU HUI</creatorcontrib><creatorcontrib>PARKER RAYMOND SAMUEL III</creatorcontrib><creatorcontrib>GLASS JOHN IRVIN</creatorcontrib><creatorcontrib>JIN LING</creatorcontrib><creatorcontrib>GARCIA-PAREDES CRISTINA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TEBBE MARK JOSEPH</au><au>WANG Q. MAY</au><au>COLLADO IVAN</au><au>BABINE ROBERT EWDARD</au><au>GUO DEQI</au><au>LAMAR JASON ERIC</au><au>SNYDER NANCY JUNE</au><au>VICTOR FRANTZ</au><au>YIP YVONNE YEE MAI</au><au>SUN XICHENG DAVID</au><au>CHEN SHU HUI</au><au>PARKER RAYMOND SAMUEL III</au><au>GLASS JOHN IRVIN</au><au>JIN LING</au><au>GARCIA-PAREDES CRISTINA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PEPTIDOMIMETIC PROTEASE INHIBITORS</title><date>2012-03-30</date><risdate>2012</risdate><abstract>The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; pol |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | PEPTIDOMIMETIC PROTEASE INHIBITORS |
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