PROTEASE RESISTANT INSULIN ANALOGUES

The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insuli...

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Hauptverfasser: LUDVIGSEN SVEND, NIELSEN PETER KRESTEN, NØRGAARD PER, LAUTRUP-LARSEN INGER, RIBEL-MADSEN ULLA, BALSCHMIDT PER, HUBALEK FRANTISEK, HAVELUND SVEND
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creator LUDVIGSEN SVEND
NIELSEN PETER KRESTEN
NØRGAARD PER
LAUTRUP-LARSEN INGER
RIBEL-MADSEN ULLA
BALSCHMIDT PER
HUBALEK FRANTISEK
HAVELUND SVEND
description The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title PROTEASE RESISTANT INSULIN ANALOGUES
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