Novel derivatives of genistein and pharmacological agents containing such derivatives
Genistein derivatives of Formula (1), wherein R1 and R2 are the same or different and independently represent hydrogen atom, alkyl, aryl, alkyloaryl, alkylcarbonyl, arylcarbonyl, while each of the above mentioned groups may be substituted in a chain or ring by amino, nitro or nitrile groups, R5(R6)R...
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| creator | ACHMATOWICZ OSMAN WANDZIK ILONA OPOLSKI ADAM WIETRZYK JOANNA KRZECZY SKI PIOTR SZELEJEWSKI WIES AW BORYSKI JERZY PUCKO WIES AW RADZIKOWSKI CZES AW PASTUCH-GAWO EK GABRIELA POLKOWSKI KRZYSZTOF GRYNKIEWICZ GRZEGORZ SKIERSKI JANUSZ SZEJA WIES AW MAZUREK ALEKSANDER P SZECHNER BARBARA |
| description | Genistein derivatives of Formula (1), wherein R1 and R2 are the same or different and independently represent hydrogen atom, alkyl, aryl, alkyloaryl, alkylcarbonyl, arylcarbonyl, while each of the above mentioned groups may be substituted in a chain or ring by amino, nitro or nitrile groups, R5(R6)R7-Si- group wherein R5, R6 and R7 are the same or different and denote C1-6alkyl or aryl, mono-, di- or oligosaccharide group while at least one hydroxyl group of saccharide group may be substituted by the same or different acyl, alkyl, acyloxyalkyl or aryl groups; R3 represents hydrogen atom or -COCH3 group; and R4 represents hydrogen atom, -SO3H, SO3 or -NH2 or -NO2 group; and their pharmaceutically acceptable salts exhibit antyproliferative and antitumour activity. New derivatives and pharmaceutical preparations containing them may be suitable in clinical oncology and/or chemoprevention of neoplasms. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_PL205635BB1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>PL205635BB1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_PL205635BB13</originalsourceid><addsrcrecordid>eNqNjDEOwjAMALMwIOAP_gASUJUHFFF1QIgB5spK3dRSsKM65P0wMDAy3XCnW7rHVQtFGGjmgpkLGegIgYQtEwugDJAmnJ_oNWpgjxHwo7OBV8nIwhLAXn76fazdYsRotPly5aA930_dlpL2ZAk9CeX-djns6mNVN82--iN5A9AzOcU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Novel derivatives of genistein and pharmacological agents containing such derivatives</title><source>esp@cenet</source><creator>ACHMATOWICZ OSMAN ; WANDZIK ILONA ; OPOLSKI ADAM ; WIETRZYK JOANNA ; KRZECZY SKI PIOTR ; SZELEJEWSKI WIES AW ; BORYSKI JERZY ; PUCKO WIES AW ; RADZIKOWSKI CZES AW ; PASTUCH-GAWO EK GABRIELA ; POLKOWSKI KRZYSZTOF ; GRYNKIEWICZ GRZEGORZ ; SKIERSKI JANUSZ ; SZEJA WIES AW ; MAZUREK ALEKSANDER P ; SZECHNER BARBARA</creator><creatorcontrib>ACHMATOWICZ OSMAN ; WANDZIK ILONA ; OPOLSKI ADAM ; WIETRZYK JOANNA ; KRZECZY SKI PIOTR ; SZELEJEWSKI WIES AW ; BORYSKI JERZY ; PUCKO WIES AW ; RADZIKOWSKI CZES AW ; PASTUCH-GAWO EK GABRIELA ; POLKOWSKI KRZYSZTOF ; GRYNKIEWICZ GRZEGORZ ; SKIERSKI JANUSZ ; SZEJA WIES AW ; MAZUREK ALEKSANDER P ; SZECHNER BARBARA</creatorcontrib><description>Genistein derivatives of Formula (1), wherein R1 and R2 are the same or different and independently represent hydrogen atom, alkyl, aryl, alkyloaryl, alkylcarbonyl, arylcarbonyl, while each of the above mentioned groups may be substituted in a chain or ring by amino, nitro or nitrile groups, R5(R6)R7-Si- group wherein R5, R6 and R7 are the same or different and denote C1-6alkyl or aryl, mono-, di- or oligosaccharide group while at least one hydroxyl group of saccharide group may be substituted by the same or different acyl, alkyl, acyloxyalkyl or aryl groups; R3 represents hydrogen atom or -COCH3 group; and R4 represents hydrogen atom, -SO3H, SO3<-> or -NH2 or -NO2 group; and their pharmaceutically acceptable salts exhibit antyproliferative and antitumour activity. New derivatives and pharmaceutical preparations containing them may be suitable in clinical oncology and/or chemoprevention of neoplasms.</description><language>eng ; pol</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100531&DB=EPODOC&CC=PL&NR=205635B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100531&DB=EPODOC&CC=PL&NR=205635B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ACHMATOWICZ OSMAN</creatorcontrib><creatorcontrib>WANDZIK ILONA</creatorcontrib><creatorcontrib>OPOLSKI ADAM</creatorcontrib><creatorcontrib>WIETRZYK JOANNA</creatorcontrib><creatorcontrib>KRZECZY SKI PIOTR</creatorcontrib><creatorcontrib>SZELEJEWSKI WIES AW</creatorcontrib><creatorcontrib>BORYSKI JERZY</creatorcontrib><creatorcontrib>PUCKO WIES AW</creatorcontrib><creatorcontrib>RADZIKOWSKI CZES AW</creatorcontrib><creatorcontrib>PASTUCH-GAWO EK GABRIELA</creatorcontrib><creatorcontrib>POLKOWSKI KRZYSZTOF</creatorcontrib><creatorcontrib>GRYNKIEWICZ GRZEGORZ</creatorcontrib><creatorcontrib>SKIERSKI JANUSZ</creatorcontrib><creatorcontrib>SZEJA WIES AW</creatorcontrib><creatorcontrib>MAZUREK ALEKSANDER P</creatorcontrib><creatorcontrib>SZECHNER BARBARA</creatorcontrib><title>Novel derivatives of genistein and pharmacological agents containing such derivatives</title><description>Genistein derivatives of Formula (1), wherein R1 and R2 are the same or different and independently represent hydrogen atom, alkyl, aryl, alkyloaryl, alkylcarbonyl, arylcarbonyl, while each of the above mentioned groups may be substituted in a chain or ring by amino, nitro or nitrile groups, R5(R6)R7-Si- group wherein R5, R6 and R7 are the same or different and denote C1-6alkyl or aryl, mono-, di- or oligosaccharide group while at least one hydroxyl group of saccharide group may be substituted by the same or different acyl, alkyl, acyloxyalkyl or aryl groups; R3 represents hydrogen atom or -COCH3 group; and R4 represents hydrogen atom, -SO3H, SO3<-> or -NH2 or -NO2 group; and their pharmaceutically acceptable salts exhibit antyproliferative and antitumour activity. New derivatives and pharmaceutical preparations containing them may be suitable in clinical oncology and/or chemoprevention of neoplasms.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEOwjAMALMwIOAP_gASUJUHFFF1QIgB5spK3dRSsKM65P0wMDAy3XCnW7rHVQtFGGjmgpkLGegIgYQtEwugDJAmnJ_oNWpgjxHwo7OBV8nIwhLAXn76fazdYsRotPly5aA930_dlpL2ZAk9CeX-djns6mNVN82--iN5A9AzOcU</recordid><startdate>20100531</startdate><enddate>20100531</enddate><creator>ACHMATOWICZ OSMAN</creator><creator>WANDZIK ILONA</creator><creator>OPOLSKI ADAM</creator><creator>WIETRZYK JOANNA</creator><creator>KRZECZY SKI PIOTR</creator><creator>SZELEJEWSKI WIES AW</creator><creator>BORYSKI JERZY</creator><creator>PUCKO WIES AW</creator><creator>RADZIKOWSKI CZES AW</creator><creator>PASTUCH-GAWO EK GABRIELA</creator><creator>POLKOWSKI KRZYSZTOF</creator><creator>GRYNKIEWICZ GRZEGORZ</creator><creator>SKIERSKI JANUSZ</creator><creator>SZEJA WIES AW</creator><creator>MAZUREK ALEKSANDER P</creator><creator>SZECHNER BARBARA</creator><scope>EVB</scope></search><sort><creationdate>20100531</creationdate><title>Novel derivatives of genistein and pharmacological agents containing such derivatives</title><author>ACHMATOWICZ OSMAN ; WANDZIK ILONA ; OPOLSKI ADAM ; WIETRZYK JOANNA ; KRZECZY SKI PIOTR ; SZELEJEWSKI WIES AW ; BORYSKI JERZY ; PUCKO WIES AW ; RADZIKOWSKI CZES AW ; PASTUCH-GAWO EK GABRIELA ; POLKOWSKI KRZYSZTOF ; GRYNKIEWICZ GRZEGORZ ; SKIERSKI JANUSZ ; SZEJA WIES AW ; MAZUREK ALEKSANDER P ; SZECHNER BARBARA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PL205635BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; pol</language><creationdate>2010</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>ACHMATOWICZ OSMAN</creatorcontrib><creatorcontrib>WANDZIK ILONA</creatorcontrib><creatorcontrib>OPOLSKI ADAM</creatorcontrib><creatorcontrib>WIETRZYK JOANNA</creatorcontrib><creatorcontrib>KRZECZY SKI PIOTR</creatorcontrib><creatorcontrib>SZELEJEWSKI WIES AW</creatorcontrib><creatorcontrib>BORYSKI JERZY</creatorcontrib><creatorcontrib>PUCKO WIES AW</creatorcontrib><creatorcontrib>RADZIKOWSKI CZES AW</creatorcontrib><creatorcontrib>PASTUCH-GAWO EK GABRIELA</creatorcontrib><creatorcontrib>POLKOWSKI KRZYSZTOF</creatorcontrib><creatorcontrib>GRYNKIEWICZ GRZEGORZ</creatorcontrib><creatorcontrib>SKIERSKI JANUSZ</creatorcontrib><creatorcontrib>SZEJA WIES AW</creatorcontrib><creatorcontrib>MAZUREK ALEKSANDER P</creatorcontrib><creatorcontrib>SZECHNER BARBARA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ACHMATOWICZ OSMAN</au><au>WANDZIK ILONA</au><au>OPOLSKI ADAM</au><au>WIETRZYK JOANNA</au><au>KRZECZY SKI PIOTR</au><au>SZELEJEWSKI WIES AW</au><au>BORYSKI JERZY</au><au>PUCKO WIES AW</au><au>RADZIKOWSKI CZES AW</au><au>PASTUCH-GAWO EK GABRIELA</au><au>POLKOWSKI KRZYSZTOF</au><au>GRYNKIEWICZ GRZEGORZ</au><au>SKIERSKI JANUSZ</au><au>SZEJA WIES AW</au><au>MAZUREK ALEKSANDER P</au><au>SZECHNER BARBARA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel derivatives of genistein and pharmacological agents containing such derivatives</title><date>2010-05-31</date><risdate>2010</risdate><abstract>Genistein derivatives of Formula (1), wherein R1 and R2 are the same or different and independently represent hydrogen atom, alkyl, aryl, alkyloaryl, alkylcarbonyl, arylcarbonyl, while each of the above mentioned groups may be substituted in a chain or ring by amino, nitro or nitrile groups, R5(R6)R7-Si- group wherein R5, R6 and R7 are the same or different and denote C1-6alkyl or aryl, mono-, di- or oligosaccharide group while at least one hydroxyl group of saccharide group may be substituted by the same or different acyl, alkyl, acyloxyalkyl or aryl groups; R3 represents hydrogen atom or -COCH3 group; and R4 represents hydrogen atom, -SO3H, SO3<-> or -NH2 or -NO2 group; and their pharmaceutically acceptable salts exhibit antyproliferative and antitumour activity. New derivatives and pharmaceutical preparations containing them may be suitable in clinical oncology and/or chemoprevention of neoplasms.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | Novel derivatives of genistein and pharmacological agents containing such derivatives |
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