Method for preparing moxifloxacin and moxifloxacin hydrochloride

Method for preparing moxifloxacin and moxifloxacin hydrochloride

The present invention relates to a "one pot" method for preparing moxifloxacin and its chlorhydrate salt, without need to isolate the intermediate compounds. The new method allows the end product moxifloxacin to be obtained on a large scale with a good yield and in pure form by using a &qu...

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Hauptverfasser: PALOMO NICOLAU, FRANCISCO, FERNANDEZ LLORCA, SARA PENÉLOPE, VILLASANTE PRIETO, JAVIER, COSME GOMEZ, ANTONIO, MOLINA PONCE, ANDRÉS
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Sprache:eng ; pol
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator PALOMO NICOLAU, FRANCISCO
FERNANDEZ LLORCA, SARA PENÉLOPE
VILLASANTE PRIETO, JAVIER
COSME GOMEZ, ANTONIO
MOLINA PONCE, ANDRÉS
description The present invention relates to a "one pot" method for preparing moxifloxacin and its chlorhydrate salt, without need to isolate the intermediate compounds. The new method allows the end product moxifloxacin to be obtained on a large scale with a good yield and in pure form by using a "one pot" method in which a smaller amount of bicyclic amine is used, this being an expensive reagent. Moreover, this method avoids and reduces the times and costs resulting from isolation of the intermediates, and substantially avoids obtaining the impurity produced by demethylation in 8-position of the ring.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Method for preparing moxifloxacin and moxifloxacin hydrochloride
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