18-METHYL-19-NOR-17-PREGN-4-EN-21,17-CARBOLACTONES AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME
The invention relates to novel 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones of general formula (I), where Z=O, H2, -NOR or -NNHSO2R, where R=H, a straight- or branched-chain 1-4 or 3-4 C alkyl group, R4=H, halogen, methyl or trifluoromethyl, R6 and/or R7 can be alpha- or beta-positioned and in...
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| creator | FRITZEMEIER, KARL-HEINRICH BOHLMANN, ROLF MUHN, HANS-PETER KUENZER, HERMANN FUHRMANN, ULRIKE PRELLE, KATJA BORDEN (FRÜHER KURZ), STEFFEN ESPERLING, PETER BITTLER, DIETER |
| description | The invention relates to novel 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones of general formula (I), where Z=O, H2, -NOR or -NNHSO2R, where R=H, a straight- or branched-chain 1-4 or 3-4 C alkyl group, R4=H, halogen, methyl or trifluoromethyl, R6 and/or R7 can be alpha- or beta-positioned and independently=branched- or straight-chain 1-4 or 3-4 alkyl, or R6=H and R7=a- or beta-positioned, straight- or branched-chain 1-4 or 3-4 C alkyl, or R6 and R7=H, or R6 and R7 together=a- or beta-positioned methylene or an additional bond. The novel compounds have gestagenic and antimineralocorticoid activity and are suitable for the production of pharmaceutical preparations, for example, for oral contraception and the treatment of pre-, peri- and post-menopausal pain. |
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The novel compounds have gestagenic and antimineralocorticoid activity and are suitable for the production of pharmaceutical preparations, for example, for oral contraception and the treatment of pre-, peri- and post-menopausal pain.</description><language>eng ; pol</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100129&DB=EPODOC&CC=PL&NR=1831240T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100129&DB=EPODOC&CC=PL&NR=1831240T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FRITZEMEIER, KARL-HEINRICH</creatorcontrib><creatorcontrib>BOHLMANN, ROLF</creatorcontrib><creatorcontrib>MUHN, HANS-PETER</creatorcontrib><creatorcontrib>KUENZER, HERMANN</creatorcontrib><creatorcontrib>FUHRMANN, ULRIKE</creatorcontrib><creatorcontrib>PRELLE, KATJA</creatorcontrib><creatorcontrib>BORDEN (FRÜHER KURZ), STEFFEN</creatorcontrib><creatorcontrib>ESPERLING, PETER</creatorcontrib><creatorcontrib>BITTLER, DIETER</creatorcontrib><title>18-METHYL-19-NOR-17-PREGN-4-EN-21,17-CARBOLACTONES AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME</title><description>The invention relates to novel 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones of general formula (I), where Z=O, H2, -NOR or -NNHSO2R, where R=H, a straight- or branched-chain 1-4 or 3-4 C alkyl group, R4=H, halogen, methyl or trifluoromethyl, R6 and/or R7 can be alpha- or beta-positioned and independently=branched- or straight-chain 1-4 or 3-4 alkyl, or R6=H and R7=a- or beta-positioned, straight- or branched-chain 1-4 or 3-4 C alkyl, or R6 and R7=H, or R6 and R7 together=a- or beta-positioned methylene or an additional bond. 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The novel compounds have gestagenic and antimineralocorticoid activity and are suitable for the production of pharmaceutical preparations, for example, for oral contraception and the treatment of pre-, peri- and post-menopausal pain.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | 18-METHYL-19-NOR-17-PREGN-4-EN-21,17-CARBOLACTONES AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME |
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