CHROMATOGRAPHY MATRIX

The present invention relates to a chromatography ligand defined by the following formula R1-R2-N(R3)-R4-R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon c...

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Hauptverfasser: ENGSTRAND CARINA, JOHANSSON BO-LENNART, MALOISEL JEAN-LUC, JOHANSSON HANS J, GLAD GUNNAR, FORSS ANNIKA
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creator ENGSTRAND CARINA
JOHANSSON BO-LENNART
MALOISEL JEAN-LUC
JOHANSSON HANS J
GLAD GUNNAR
FORSS ANNIKA
description The present invention relates to a chromatography ligand defined by the following formula R1-R2-N(R3)-R4-R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a hydrocarbon chain comprising 0-4 carbon atoms; R3 is a hydrocarbon chain comprising 1-3 carbon atoms; R4 is a hydrocarbon chain comprising 1-5 carbon atoms; and R5 is OH or H. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane. The ligand and matrix according to the invention is useful for purification of biomolecules or organic compounds, such as proteins, polypeptides, DNA etc. An advantageous use according to the invention is the purification of antibodies.
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subjects CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
THEIR RELEVANT APPARATUS
TRANSPORTING
title CHROMATOGRAPHY MATRIX
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