METHOD OF OBTAINING 1-HYDROXY-2-NAPHTALENECARBOXYLIC SALT OF 4-HYDROXY-ALPHA-[[[6-(4-PHENYLOBUTOXY)-HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL IN NOVEL FORM

1-Hydroxy-2-naphthalene carboxylate (hydroxynaphthoate) salt of 4-hydroxy- alpha -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3- benzenedimethanol in the form of spherical accretions of microcrystals, the spherical accretions being free-flowing, friable and micronisable and preferably having a mean p...

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Hauptverfasser: SIDGWICK COLIN B, ROBERTS TONY G, LATHAM DAVID W. S, BEACH STEVEN F
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creator SIDGWICK COLIN B
ROBERTS TONY G
LATHAM DAVID W. S
BEACH STEVEN F
description 1-Hydroxy-2-naphthalene carboxylate (hydroxynaphthoate) salt of 4-hydroxy- alpha -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3- benzenedimethanol in the form of spherical accretions of microcrystals, the spherical accretions being free-flowing, friable and micronisable and preferably having a mean particle size from 70 to 300 mu m and a mean surface area from 4 to 12m g- . The hydroxynaphthoate salt (in the claimed form) may be prepared by quenching a hot organic/aqueous organic solution containing the salt with a cold organic/aqueous organic solvent.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
CRUSHING, PULVERISING, OR DISINTEGRATING
CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MILLING GRAIN
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PREPARATORY TREATMENT OF GRAIN FOR MILLING
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
title METHOD OF OBTAINING 1-HYDROXY-2-NAPHTALENECARBOXYLIC SALT OF 4-HYDROXY-ALPHA-[[[6-(4-PHENYLOBUTOXY)-HEXYL]AMINO]METHYL]-1,3-BENZENEDIMETHANOL IN NOVEL FORM
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