Positive inotropic and lusitropic 3,5-dihydroimidazoÚ2,1-b¾ quinazolin-2(1H)-one derivatives
Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substitute...
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| creator | EDDY J. E. FREYNE ALFONS H. M. RAEYMAEKERS |
| description | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R is hydrogen of C1-6alkyl; R is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R and R taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R (b),or =CH-R (c); R is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R ; R is COOH, COOC1-4alkyl, CONR R , COOCH2CONR R or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R . Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions. |
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RAEYMAEKERS</creatorcontrib><description>Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R is hydrogen of C1-6alkyl; R is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R and R taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R (b),or =CH-R (c); R is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R ; R is COOH, COOC1-4alkyl, CONR R , COOCH2CONR R or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R . Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.</description><edition>5</edition><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1993</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930316&DB=EPODOC&CC=PH&NR=27111A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930316&DB=EPODOC&CC=PH&NR=27111A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>EDDY J. E. FREYNE</creatorcontrib><creatorcontrib>ALFONS H. M. RAEYMAEKERS</creatorcontrib><title>Positive inotropic and lusitropic 3,5-dihydroimidazoÚ2,1-b¾ quinazolin-2(1H)-one derivatives</title><description>Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R is hydrogen of C1-6alkyl; R is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R and R taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R (b),or =CH-R (c); R is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R ; R is COOH, COOC1-4alkyl, CONR R , COOCH2CONR R or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R . Pharmaceutical compositions containing said compounds as an active ingredient. 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E. FREYNE</creator><creator>ALFONS H. M. RAEYMAEKERS</creator><scope>EVB</scope></search><sort><creationdate>19930316</creationdate><title>Positive inotropic and lusitropic 3,5-dihydroimidazoÚ2,1-b¾ quinazolin-2(1H)-one derivatives</title><author>EDDY J. E. FREYNE ; ALFONS H. M. RAEYMAEKERS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PH27111A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1993</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>EDDY J. E. FREYNE</creatorcontrib><creatorcontrib>ALFONS H. M. RAEYMAEKERS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>EDDY J. E. FREYNE</au><au>ALFONS H. M. RAEYMAEKERS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Positive inotropic and lusitropic 3,5-dihydroimidazoÚ2,1-b¾ quinazolin-2(1H)-one derivatives</title><date>1993-03-16</date><risdate>1993</risdate><abstract>Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives of formula the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein R is hydrogen, C1-6alkyl, phenyl; substituted phenyl; pyridinyl; or thienyl optionally substituted with halo or C1-6alkyl; R is hydrogen of C1-6alkyl; R is hydrogen, C1-6alkyl, hydroxyC1-6alkyl or phenyl; or R and R taken together may also form a C1-5alkanediyl radical; X is a radical of formula =O (a), =N-O-R (b),or =CH-R (c); R is hydrogen, tri(C1-6alkyl)silyl or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R ; R is COOH, COOC1-4alkyl, CONR R , COOCH2CONR R or C1-6alkyl optionally substituted with COOH, COOC1-4alkyl, CONR R or COOCH2CONR R . Pharmaceutical compositions containing said compounds as an active ingredient. Methods of preparing said compounds and pharmaceutical compositions.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Positive inotropic and lusitropic 3,5-dihydroimidazoÚ2,1-b¾ quinazolin-2(1H)-one derivatives |
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