NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutica...
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| creator | BREHMER, Dirk MEERPOEL, Lieven VIELLEVOYE, Marcel DIELS, Gaston, Stanislas, Marcella SUN, Weimei LAWSON, Edward, Charles BEKE, Lijs WU, Tongfei GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph PANDE, Vineet THURING, Johannes, Wilhelmus, John, F SCHEPENS, Wim, Bert, Griet BOECKX, An PARADE, Marcus, Cornelis, Bernardus, Catharina |
| description | The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
| format | Patent |
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The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220502&DB=EPODOC&CC=PH&NR=12021552054A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220502&DB=EPODOC&CC=PH&NR=12021552054A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BREHMER, Dirk</creatorcontrib><creatorcontrib>MEERPOEL, Lieven</creatorcontrib><creatorcontrib>VIELLEVOYE, Marcel</creatorcontrib><creatorcontrib>DIELS, Gaston, Stanislas, Marcella</creatorcontrib><creatorcontrib>SUN, Weimei</creatorcontrib><creatorcontrib>LAWSON, Edward, Charles</creatorcontrib><creatorcontrib>BEKE, Lijs</creatorcontrib><creatorcontrib>WU, Tongfei</creatorcontrib><creatorcontrib>GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph</creatorcontrib><creatorcontrib>PANDE, Vineet</creatorcontrib><creatorcontrib>THURING, Johannes, Wilhelmus, John, F</creatorcontrib><creatorcontrib>SCHEPENS, Wim, Bert, Griet</creatorcontrib><creatorcontrib>BOECKX, An</creatorcontrib><creatorcontrib>PARADE, Marcus, Cornelis, Bernardus, Catharina</creatorcontrib><title>NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS</title><description>The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. 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The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS |
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