MONOCLONAL ANTIBODIES AGAINST THE BETA CHAIN REGION OF HUMAN TRBV9

The invention relates to a monoclonal humanized antibody or an antigen-binding fragment thereof which bind specifically to the TRBV9 family of human ?-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, an expression...

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Hauptverfasser:	STAROVEROV, Dmitry Borisovich, IAKOVLEV, Pavel Andreevich, BRITANOVA, ?lga Vladimirovna, NEMANKIN, Timofey Aleksandrovich, MOROZOV, Dmitry Valentinovich, MISORIN, Alexey Konstantinovich, VLADIMIROVA, Anna Konstantinovna, EVSTRATEVA, Anna Valentinovna, IVANOV, Roman Alekseevich, LUKYANOV, Sergey Anatolievich, SHELEVA, Mariia Aleksandrovna, ANIKINA, Arina Vitalevna
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a monoclonal humanized antibody or an antigen-binding fragment thereof which bind specifically to the TRBV9 family of human ?-cell receptors. The invention also relates to a nucleic acid which codes for said antibody or for an antigen-binding fragment thereof, an expression vector, a method for producing the antibody, and the use of said antibody for treating diseases or disorders associated with said family of human T-cell receptors. The invention is directed towards producing antibodies which can be used, in particular, for treating ankylosing spondylitis (AS or Bekhterev's disease), coeliac disease and blood cancers, the pathogenesis of which involves T-cell receptors of the TRBV9 family.