PROCESS FOR THE HYDROLYSIS OF QUINOLONE CARBOXYLIC ESTERS

PROCESS FOR THE HYDROLYSIS OF QUINOLONE CARBOXYLIC ESTERS

Quinolone carboxylic esters of general formula (II) are hydrolyzed to form quinolone carboxylic acids of general formula (I): the method comprises the step A): A) reacting compounds of formula (II) with a mixture that comprises acetic acid, sulfuric acid and water. In step A), = 30 to = 40 mol aceti...

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Hauptverfasser: BERWE, Mathias, DIETZEL, Antje, FEY, Peter, WIRTHS, J”rg, LONGERICH, Markus, WISCHNAT, Ralf
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator BERWE, Mathias
DIETZEL, Antje
FEY, Peter
WIRTHS, J”rg
LONGERICH, Markus
WISCHNAT, Ralf
description Quinolone carboxylic esters of general formula (II) are hydrolyzed to form quinolone carboxylic acids of general formula (I): the method comprises the step A): A) reacting compounds of formula (II) with a mixture that comprises acetic acid, sulfuric acid and water. In step A), = 30 to = 40 mol acetic acid, = 0.3 to = 1 mol sulfuric acid and = 0.9 to = 2.5 mol water are used per mol of compounds of formula (II). The process according to the invention is particularly suitable for the synthesis of the intermediate (I) in the synthesis of pradofloxacin.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR THE HYDROLYSIS OF QUINOLONE CARBOXYLIC ESTERS
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