METHODS OF TREATMENT USING SELECTIVE BCL-2 INHIBITORS

This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl 2 anti apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively...

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Hauptverfasser: ELMORE, Steven, SOUERS, Andrew, PERPER, Stuart J, GHAYUR, Tariq, WANG, Li Chun
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creator ELMORE, Steven
SOUERS, Andrew
PERPER, Stuart J
GHAYUR, Tariq
WANG, Li Chun
description This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl 2 anti apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl- xL.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHODS OF TREATMENT USING SELECTIVE BCL-2 INHIBITORS
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