MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Phi) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphom...

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Bibliographische Detailangaben
Hauptverfasser:	JUDITH GAIL DEAL, SIMON BAILEY, NEAL WILLIAM SACH, MICHELE ANN MCTIGUE, BENJAMIN JOSEPH BURKE, PHUONG THI QUY LE, ROBERT LOUIS HOFFMAN, QINHUA HUANG, CYNTHIA LOUISE PALMER, ROBERT STEVEN KANIA, JINGRONG JEAN CUI, PAUL FRANCIS RICHARDSON, TED WILLIAM JOHNSON, JOHN CHARLES KATH, MICHAEL RAYMOND COLLINS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to compounds of formula (Phi) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.