FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER

Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en p...

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Hauptverfasser: KINOSHITA, Taisei, BUTLER, Thomas, PALMER, James T, JIANG, Siyi, TAN, Heow, LAW, Brian, SOMANATH, Priyanka, WONG, Angelina Sau Man, HE, Hongyan, LU, Daniel, LIN, Nan-Horng
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creator KINOSHITA, Taisei
BUTLER, Thomas
PALMER, James T
JIANG, Siyi
TAN, Heow
LAW, Brian
SOMANATH, Priyanka
WONG, Angelina Sau Man
HE, Hongyan
LU, Daniel
LIN, Nan-Horng
description Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en polvo que comprende picos caracteristicos en angulos 2theta, seleccionados del grupo que consiste en 3.4°±0.1° 2theta, 8.7°±0.1° 2theta, 10.7°±0.1° 2theta, entre otros. En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes. Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes. Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. 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En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes. Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. 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En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes. Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER
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