FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER
Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en p...
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creator | KINOSHITA, Taisei BUTLER, Thomas PALMER, James T JIANG, Siyi TAN, Heow LAW, Brian SOMANATH, Priyanka WONG, Angelina Sau Man HE, Hongyan LU, Daniel LIN, Nan-Horng |
description | Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en polvo que comprende picos caracteristicos en angulos 2theta, seleccionados del grupo que consiste en 3.4°±0.1° 2theta, 8.7°±0.1° 2theta, 10.7°±0.1° 2theta, entre otros. En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes.
Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. |
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Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240819&DB=EPODOC&CC=PE&NR=20241728A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240819&DB=EPODOC&CC=PE&NR=20241728A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KINOSHITA, Taisei</creatorcontrib><creatorcontrib>BUTLER, Thomas</creatorcontrib><creatorcontrib>PALMER, James T</creatorcontrib><creatorcontrib>JIANG, Siyi</creatorcontrib><creatorcontrib>TAN, Heow</creatorcontrib><creatorcontrib>LAW, Brian</creatorcontrib><creatorcontrib>SOMANATH, Priyanka</creatorcontrib><creatorcontrib>WONG, Angelina Sau Man</creatorcontrib><creatorcontrib>HE, Hongyan</creatorcontrib><creatorcontrib>LU, Daniel</creatorcontrib><creatorcontrib>LIN, Nan-Horng</creatorcontrib><title>FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER</title><description>Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en polvo que comprende picos caracteristicos en angulos 2theta, seleccionados del grupo que consiste en 3.4°±0.1° 2theta, 8.7°±0.1° 2theta, 10.7°±0.1° 2theta, entre otros. En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes.
Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjstKw1AQhrtxIeo7nO4S6IC5YN1OkgkZODemRymEUIrElWihPrYP4RzwAYSBufB9_HO7-RmDODS98CGhZY9mIONhbnMVLbggY9A72xL2E0QWCTbM9a6BYdGNHQ_s4QnYLiMptoCqc1NICWYuKgjHUEINUUIkD5VyJTr2YdE5ciTJvmqOUpbrHJFP2KN04ajsgDvz4g37iTseghj9gV5JDtxZyu86zfUIzloTUdCQNUkwqUo-BSWs6dH3JPebm_fzx3V9-Ot3m-1IqZ9gvXyd1uvl_LZ-rt-nSPVj3Vb7-hmr5j_ML67AWDw</recordid><startdate>20240819</startdate><enddate>20240819</enddate><creator>KINOSHITA, Taisei</creator><creator>BUTLER, Thomas</creator><creator>PALMER, James T</creator><creator>JIANG, Siyi</creator><creator>TAN, Heow</creator><creator>LAW, Brian</creator><creator>SOMANATH, Priyanka</creator><creator>WONG, Angelina Sau Man</creator><creator>HE, Hongyan</creator><creator>LU, Daniel</creator><creator>LIN, Nan-Horng</creator><scope>EVB</scope></search><sort><creationdate>20240819</creationdate><title>FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER</title><author>KINOSHITA, Taisei ; BUTLER, Thomas ; PALMER, James T ; JIANG, Siyi ; TAN, Heow ; LAW, Brian ; SOMANATH, Priyanka ; WONG, Angelina Sau Man ; HE, Hongyan ; LU, Daniel ; LIN, Nan-Horng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PE20241728A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KINOSHITA, Taisei</creatorcontrib><creatorcontrib>BUTLER, Thomas</creatorcontrib><creatorcontrib>PALMER, James T</creatorcontrib><creatorcontrib>JIANG, Siyi</creatorcontrib><creatorcontrib>TAN, Heow</creatorcontrib><creatorcontrib>LAW, Brian</creatorcontrib><creatorcontrib>SOMANATH, Priyanka</creatorcontrib><creatorcontrib>WONG, Angelina Sau Man</creatorcontrib><creatorcontrib>HE, Hongyan</creatorcontrib><creatorcontrib>LU, Daniel</creatorcontrib><creatorcontrib>LIN, Nan-Horng</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KINOSHITA, Taisei</au><au>BUTLER, Thomas</au><au>PALMER, James T</au><au>JIANG, Siyi</au><au>TAN, Heow</au><au>LAW, Brian</au><au>SOMANATH, Priyanka</au><au>WONG, Angelina Sau Man</au><au>HE, Hongyan</au><au>LU, Daniel</au><au>LIN, Nan-Horng</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER</title><date>2024-08-19</date><risdate>2024</risdate><abstract>Se refiere a una forma cristalina D de N-[4-[4-(4-morfolinil)-7H-pirrolo[2,3-d]pirimidin-6-il]fenil]-4-[[3(R)-[ (1-oxo-2-propen-1-il)amino]-1-piperidinil]metil]-2-piridincarboxamida (Compuesto A) de Formula I, en la que la Forma cristalina D se caracteriza por un patron de difraccion de rayos X en polvo que comprende picos caracteristicos en angulos 2theta, seleccionados del grupo que consiste en 3.4°±0.1° 2theta, 8.7°±0.1° 2theta, 10.7°±0.1° 2theta, entre otros. En donde dicho compuesto es un inhibidor irreversible de menina-MLL. Tambien se refiere a un proceso para preparar la forma cristalina D de dicho compuesto, una composicion farmaceutica que lo comprende y su uso en el tratamiento del cancer, tales como linfoma y leucemia, y enfermedades autoinmunes.
Described herein is N-[4-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(R)-[(1-oxo-2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, including crystalline forms, solvates, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the compound, as well as methods of using the compound, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | FORMA CRISTALINA DE N-[4-[4-(4-MORFOLINIL)-7H-PIRROLO[2,3-D]PIRIMIDIN-6-IL]FENIL]-4-[[3(R)- [(1-OXO)-2-PROPEN-1-IL)AMINO]-1-PIPERIDINIL]METIL]-2-PIRIDINACARBOXAMIDA, UN INHIBIDOR IRREVERSIBLE DE MENINA-MLL PARA EL TRATAMIENTO DEL CANCER |
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