OLIGONUCLEOTIDOS PARA MODULAR LA EXPRESION DE RTEL1
La presente invencion se refiere a un inhibidor de RTEL1 para usar en el tratamiento de una infeccion por HBV, en particular, una infeccion por HBV cronica. La invencion se refiere, en particular, al uso de inhibidores de RTEL1 para desestabilizar cccADN, tal como cccADN de HBV. La invencion tambien...
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| creator | KAM-THONG, Tony LEONARD, Brian BERRERA, Marco WALLIER, Angelina KAMMLER, Susanne FELBER, Josephine TROPBERGER, Philipp HOFLACK, Jean-Christophe TRIYATNI, Miriam TURLEY, Daniel Jeremy PEDERSEN, Lykke ZHANG, Jitao David |
| description | La presente invencion se refiere a un inhibidor de RTEL1 para usar en el tratamiento de una infeccion por HBV, en particular, una infeccion por HBV cronica. La invencion se refiere, en particular, al uso de inhibidores de RTEL1 para desestabilizar cccADN, tal como cccADN de HBV. La invencion tambien se refiere a oligonucleotidos antisentido que son complementarios de RTEL1 y que pueden reducir el mARN de RTEL1. La presente invencion tambien abarca una composicion farmaceutica y su uso en el tratamiento y/o prevencion de una infeccion por HBV.
The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection. |
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The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.</description><language>spa</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210720&DB=EPODOC&CC=PE&NR=20211306A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210720&DB=EPODOC&CC=PE&NR=20211306A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAM-THONG, Tony</creatorcontrib><creatorcontrib>LEONARD, Brian</creatorcontrib><creatorcontrib>BERRERA, Marco</creatorcontrib><creatorcontrib>WALLIER, Angelina</creatorcontrib><creatorcontrib>KAMMLER, Susanne</creatorcontrib><creatorcontrib>FELBER, Josephine</creatorcontrib><creatorcontrib>TROPBERGER, Philipp</creatorcontrib><creatorcontrib>HOFLACK, Jean-Christophe</creatorcontrib><creatorcontrib>TRIYATNI, Miriam</creatorcontrib><creatorcontrib>TURLEY, Daniel Jeremy</creatorcontrib><creatorcontrib>PEDERSEN, Lykke</creatorcontrib><creatorcontrib>ZHANG, Jitao David</creatorcontrib><title>OLIGONUCLEOTIDOS PARA MODULAR LA EXPRESION DE RTEL1</title><description>La presente invencion se refiere a un inhibidor de RTEL1 para usar en el tratamiento de una infeccion por HBV, en particular, una infeccion por HBV cronica. La invencion se refiere, en particular, al uso de inhibidores de RTEL1 para desestabilizar cccADN, tal como cccADN de HBV. La invencion tambien se refiere a oligonucleotidos antisentido que son complementarios de RTEL1 y que pueden reducir el mARN de RTEL1. La presente invencion tambien abarca una composicion farmaceutica y su uso en el tratamiento y/o prevencion de una infeccion por HBV.
The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. 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La invencion se refiere, en particular, al uso de inhibidores de RTEL1 para desestabilizar cccADN, tal como cccADN de HBV. La invencion tambien se refiere a oligonucleotidos antisentido que son complementarios de RTEL1 y que pueden reducir el mARN de RTEL1. La presente invencion tambien abarca una composicion farmaceutica y su uso en el tratamiento y/o prevencion de una infeccion por HBV.
The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | OLIGONUCLEOTIDOS PARA MODULAR LA EXPRESION DE RTEL1 |
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