COMPUESTOS DE AZETIDINILOXIFENILPIRROLIDINA
Se refiere a derivados de azetidiniloxifenilpirrolidina de la formula general, en donde: R1 es CH3, CD3, CN, Cl, CF3; y R es una de las formulas detalladas a continuacion. Estos compuestos son inhibidores de la PDE4 y se emplean en el tratamiento de la vejiga hiperactiva, incluso para aliviar sintom...
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| creator | DENG, Gary G JESUDASON, Cynthia Darshini HUANG, Danwen ODINGO, Joshua O |
| description | Se refiere a derivados de azetidiniloxifenilpirrolidina de la formula general, en donde: R1 es CH3, CD3, CN, Cl, CF3; y R es una de las formulas detalladas a continuacion. Estos compuestos son inhibidores de la PDE4 y se emplean en el tratamiento de la vejiga hiperactiva, incluso para aliviar sintomas asociados tales como la frecuencia y la urgencia, y otros trastornos. Entre los compuestos preferidos tenemos al siguiente: (2S)-3-[(3S,4S)-3-[(1R)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-cloropiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol
The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat overactive bladder. |
| format | Patent |
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The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat overactive bladder.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB29vcNCHUNDvEPVnBxVXCMcg3xdPH08_Txj_B0cwXSAZ5BQf4-IDFHHgbWtMSc4lReKM3NoOjmGuLsoZtakB-fWlyQmJyal1oSH-BqZGBobmBsZOFoaEyMGgCvbiVt</recordid><startdate>20170419</startdate><enddate>20170419</enddate><creator>DENG, Gary G</creator><creator>JESUDASON, Cynthia Darshini</creator><creator>HUANG, Danwen</creator><creator>ODINGO, Joshua O</creator><scope>EVB</scope></search><sort><creationdate>20170419</creationdate><title>COMPUESTOS DE AZETIDINILOXIFENILPIRROLIDINA</title><author>DENG, Gary G ; JESUDASON, Cynthia Darshini ; HUANG, Danwen ; ODINGO, Joshua O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PE20170328A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DENG, Gary G</creatorcontrib><creatorcontrib>JESUDASON, Cynthia Darshini</creatorcontrib><creatorcontrib>HUANG, Danwen</creatorcontrib><creatorcontrib>ODINGO, Joshua O</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DENG, Gary G</au><au>JESUDASON, Cynthia Darshini</au><au>HUANG, Danwen</au><au>ODINGO, Joshua O</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS DE AZETIDINILOXIFENILPIRROLIDINA</title><date>2017-04-19</date><risdate>2017</risdate><abstract>Se refiere a derivados de azetidiniloxifenilpirrolidina de la formula general, en donde: R1 es CH3, CD3, CN, Cl, CF3; y R es una de las formulas detalladas a continuacion. Estos compuestos son inhibidores de la PDE4 y se emplean en el tratamiento de la vejiga hiperactiva, incluso para aliviar sintomas asociados tales como la frecuencia y la urgencia, y otros trastornos. Entre los compuestos preferidos tenemos al siguiente: (2S)-3-[(3S,4S)-3-[(1R)-1-hidroxietil]-4-(4-metoxi-3-{[1-(5-cloropiridin-2-il)azetidin-3-il]oxi}fenil)-3-metilpirrolidin-1-il]-3-oxopropano-1,2-diol
The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat overactive bladder.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPUESTOS DE AZETIDINILOXIFENILPIRROLIDINA |
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