EL USO DE UNA COMPOSICION DE CELECOXIB PARA EL ALIVIO RAPIDO DEL DOLOR

SE REFIERE AL USO DE CELECOXIB POR VIA ORAL UTILIZANDOSE DE 50mg A 400mg; EN AYUNAS PROPORCIONA UNA CONCENTRACION EN EL PLASMA DE AL MENOS 250 ng/ml A MAS TARDAR 30 MINUTOS DESPUES DE LA ADMINISTRACION O EXHIBE UN Tmax NO MAYOR DE 1.25 HORAS; EL CELECOXIB SE FORMULA COMO UNA DISPERSION ULTRA FINA O...

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Hauptverfasser: GAO PING, FORBES JAMES C, HASSAN FRED, KARIM AZIZ, BRUGGER ANDREW M
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creator GAO PING
FORBES JAMES C
HASSAN FRED
KARIM AZIZ
BRUGGER ANDREW M
description SE REFIERE AL USO DE CELECOXIB POR VIA ORAL UTILIZANDOSE DE 50mg A 400mg; EN AYUNAS PROPORCIONA UNA CONCENTRACION EN EL PLASMA DE AL MENOS 250 ng/ml A MAS TARDAR 30 MINUTOS DESPUES DE LA ADMINISTRACION O EXHIBE UN Tmax NO MAYOR DE 1.25 HORAS; EL CELECOXIB SE FORMULA COMO UNA DISPERSION ULTRA FINA O SOLUCION EN UN MEDIO LIQUIDO O SE FORMULA COMO PARTICULAS SOLIDAS QUE TIENEN UN TAMANO D90 MENOR DE 10µm; O SE FORMULA DISOLVIENDOLO EN UN SOLVENTE ADECUADO Y AGREGANDO LA SOLUCION RESULTANTE A UN LIQUIDO ACUOSO (POLIETILENGLICOL) PARA FORMAR UNA SUSPENSION FINA QUE SE ADMINISTRA AL INDIVIDUO A MAS TARDAR 15 MINUTOS DESPUES DE LA PREPARACION. LA FORMULACION SE ENCAPSULA CON UNA PARED QUE COMPRENDE GELATINA, HIDROXIPROPILMETILCELULOSA. TAMBIEN SE REFIERE AL USO EN COMBINACION CON CODEINA, MEPERIDINA, MORFINA, CAFEINA, TEOFILINA, TEOBROMINA. There is provided a method of rapidly relieving pain in a mammalian, preferably human, subject. The method comprises orally administering to the subject an effective pain-relieving amount of a composition comprising celecoxib formulated in such a way as to provide, when tested in fasting humans in accordance with standard pharmacokinetic practice, a blood plasma concentration profile of celecoxib in which a concentration of about 250 ng/ml is attained not later than about 30 minutes after oral administration.
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language spa
recordid cdi_epo_espacenet_PE20011326A1
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subjects BABY COMFORTERS
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES
DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY
DEVICES FOR RECEIVING SPITTLE
DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title EL USO DE UNA COMPOSICION DE CELECOXIB PARA EL ALIVIO RAPIDO DEL DOLOR
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