INHIBIDORES DE NAALADASA
LA PRESENTE DIVULGACION SE RELACIONA CON LOS INHIBIDORES DE LA DIPEPTIDASA, Y MAS ESPECIALMENTE A NOVEDOSOS DERIVADOS DE FOSFONATO, DERIVADOS DE HIDROXIFOSFINILO Y DERIVADOS DE FOSFORAMIDATO QUE INHIBEN LA ACTIVIDAD ENZIMATICA DE LA DIPEPTIDASA N ACETILADA A ENLAZADA ACIDICA, COMPOSICIONES FARMACEUT...
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| creator | PAUL F. JACKSON BARBARA S. SLUSHER KEVIN L. TAYS KEITH M. MACLIN |
| description | LA PRESENTE DIVULGACION SE RELACIONA CON LOS INHIBIDORES DE LA DIPEPTIDASA, Y MAS ESPECIALMENTE A NOVEDOSOS DERIVADOS DE FOSFONATO, DERIVADOS DE HIDROXIFOSFINILO Y DERIVADOS DE FOSFORAMIDATO QUE INHIBEN LA ACTIVIDAD ENZIMATICA DE LA DIPEPTIDASA N ACETILADA A ENLAZADA ACIDICA, COMPOSICIONES FARMACEUTICAS QUE INCLUYEN DICHOS DERIVADOS Y METODOS DE USO DE DICHOS DERIVADOS PARA INHIBIR LA ACTIVIDAD DE NAALADASA Y PARA TRATAR LAS ENFERMEDADES PROSTATICAS, EN ESPECIAL CON EL USO DE LOS COMPUESTOS DEL PRESENTE INVENTO PARA LA INHIBICION DEL CRECIMIENTO DE LAS CELULAS DEL CANCER DE LA PROSTATA.
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells. |
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The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.</description><edition>7</edition><language>spa</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010731&DB=EPODOC&CC=PA&NR=8436001A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010731&DB=EPODOC&CC=PA&NR=8436001A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAUL F. JACKSON</creatorcontrib><creatorcontrib>BARBARA S. SLUSHER</creatorcontrib><creatorcontrib>KEVIN L. TAYS</creatorcontrib><creatorcontrib>KEITH M. MACLIN</creatorcontrib><title>INHIBIDORES DE NAALADASA</title><description>LA PRESENTE DIVULGACION SE RELACIONA CON LOS INHIBIDORES DE LA DIPEPTIDASA, Y MAS ESPECIALMENTE A NOVEDOSOS DERIVADOS DE FOSFONATO, DERIVADOS DE HIDROXIFOSFINILO Y DERIVADOS DE FOSFORAMIDATO QUE INHIBEN LA ACTIVIDAD ENZIMATICA DE LA DIPEPTIDASA N ACETILADA A ENLAZADA ACIDICA, COMPOSICIONES FARMACEUTICAS QUE INCLUYEN DICHOS DERIVADOS Y METODOS DE USO DE DICHOS DERIVADOS PARA INHIBIR LA ACTIVIDAD DE NAALADASA Y PARA TRATAR LAS ENFERMEDADES PROSTATICAS, EN ESPECIAL CON EL USO DE LOS COMPUESTOS DEL PRESENTE INVENTO PARA LA INHIBICION DEL CRECIMIENTO DE LAS CELULAS DEL CANCER DE LA PROSTATA.
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDw9PPwdPJ08Q9yDVZwcVXwc3T0cXRxDHbkYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxAY4WJsZmBgaGjobGRCgBAJ3hHvo</recordid><startdate>20010731</startdate><enddate>20010731</enddate><creator>PAUL F. JACKSON</creator><creator>BARBARA S. SLUSHER</creator><creator>KEVIN L. TAYS</creator><creator>KEITH M. MACLIN</creator><scope>EVB</scope></search><sort><creationdate>20010731</creationdate><title>INHIBIDORES DE NAALADASA</title><author>PAUL F. JACKSON ; BARBARA S. SLUSHER ; KEVIN L. TAYS ; KEITH M. MACLIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_PA8436001A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2001</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PAUL F. JACKSON</creatorcontrib><creatorcontrib>BARBARA S. SLUSHER</creatorcontrib><creatorcontrib>KEVIN L. TAYS</creatorcontrib><creatorcontrib>KEITH M. MACLIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAUL F. JACKSON</au><au>BARBARA S. SLUSHER</au><au>KEVIN L. TAYS</au><au>KEITH M. MACLIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBIDORES DE NAALADASA</title><date>2001-07-31</date><risdate>2001</risdate><abstract>LA PRESENTE DIVULGACION SE RELACIONA CON LOS INHIBIDORES DE LA DIPEPTIDASA, Y MAS ESPECIALMENTE A NOVEDOSOS DERIVADOS DE FOSFONATO, DERIVADOS DE HIDROXIFOSFINILO Y DERIVADOS DE FOSFORAMIDATO QUE INHIBEN LA ACTIVIDAD ENZIMATICA DE LA DIPEPTIDASA N ACETILADA A ENLAZADA ACIDICA, COMPOSICIONES FARMACEUTICAS QUE INCLUYEN DICHOS DERIVADOS Y METODOS DE USO DE DICHOS DERIVADOS PARA INHIBIR LA ACTIVIDAD DE NAALADASA Y PARA TRATAR LAS ENFERMEDADES PROSTATICAS, EN ESPECIAL CON EL USO DE LOS COMPUESTOS DEL PRESENTE INVENTO PARA LA INHIBICION DEL CRECIMIENTO DE LAS CELULAS DEL CANCER DE LA PROSTATA.
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBIDORES DE NAALADASA |
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