Stable non-hygroscopic crystalline form of n-Än-n-(piperidin-4-yl)butanoyl)-n-ethylglycylÜcompounds

The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof,...

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Bibliographische Detailangaben
Hauptverfasser:	MENCEL, JAMES, J, DAVID TOLEDO-VALASQUEZ, POWERS, MATTHEW, R, VINCENT WINDISCH, GARDETTO, ANTHONY, J, SLEDESKI, ADAM, W, VEMURI, NARASIMBA, M, CHRZAN, ZOFIA, J, SALAZAR, DIANE, C, SHERBINE, JAMES, P, WATER RODRIGUEZ, LIU, ROBERT, C, VANASSE, BENOIT, J, WOODWARD, RICK, G, KUBIAK, GREGORY, G
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)- beta -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.