Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component
The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor rece...
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| creator | Kim, Hwan Kim, Nam Doo Han, Ah Reum Ko, Yi Kyung Hwang, Dong Keun Lee, Sun Hwa Kang, Se In Lee, Youn Ho Seok, Ji Yoon Kim, Da Eun Choi, Hwan Geun Son, Jung Beom Kim, Seung Su Ryu, Min Seok Ko, Eun Hwa Kang, Ju Hee |
| description | The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer. |
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The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220826&DB=EPODOC&CC=NZ&NR=781366A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220826&DB=EPODOC&CC=NZ&NR=781366A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kim, Hwan</creatorcontrib><creatorcontrib>Kim, Nam Doo</creatorcontrib><creatorcontrib>Han, Ah Reum</creatorcontrib><creatorcontrib>Ko, Yi Kyung</creatorcontrib><creatorcontrib>Hwang, Dong Keun</creatorcontrib><creatorcontrib>Lee, Sun Hwa</creatorcontrib><creatorcontrib>Kang, Se In</creatorcontrib><creatorcontrib>Lee, Youn Ho</creatorcontrib><creatorcontrib>Seok, Ji Yoon</creatorcontrib><creatorcontrib>Kim, Da Eun</creatorcontrib><creatorcontrib>Choi, Hwan Geun</creatorcontrib><creatorcontrib>Son, Jung Beom</creatorcontrib><creatorcontrib>Kim, Seung Su</creatorcontrib><creatorcontrib>Ryu, Min Seok</creatorcontrib><creatorcontrib>Ko, Eun Hwa</creatorcontrib><creatorcontrib>Kang, Ju Hee</creatorcontrib><title>Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component</title><description>The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. 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The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component |
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