Amatoxin-antibody conjugates

The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues. The invention specifically relates to cysteine residue modifications where the conjugate has the formula (Ama-L-X-S)n-Ab and the cysteine resid...

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Bibliographische Detailangaben
Hauptverfasser:	Anderl, Jan, Mueller, Christoph, Pahl, Andreas, Hechler, Torsten
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues. The invention specifically relates to cysteine residue modifications where the conjugate has the formula (Ama-L-X-S)n-Ab and the cysteine residue is heavy chain 265Cys according to the EU numbering system, and conjugates where the amatoxin has the thioether sulfoxide moiety replaced by a sulfide. Pharmaceutical compositions of the conjugates can be used to treat disease associated with cells presenting a target specific to the selected antibody.