Pyrimidine tricyclic enone derivatives for inhibition of rorγ and other uses
Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-...
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| creator | Kornberg, Brian Jiang, Xin Lee, Chitase Bolton, Gary Sheldon, Zachary Caprathe, Bradley Bender, Christopher Hotema, Martha Visnick, Melean |
| description | Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. The compounds described herein have good RORγ inhibitory activity, despite having 'natural configuration' at the stereocenters C4, C5, and C10 in formula (I). Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyrimidine tricyclic enone derivatives for inhibition of rorγ and other uses |
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