Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and ge...

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Hauptverfasser: Morschhaeuser, Gerd, Peters, Stefan, Anderskewitz, Ralf, Ries, Uwe Joerg, Hoesch, Holger, Gnamm, Christian, Oost, Thorsten
Format: Patent
Sprache:eng
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Zusammenfassung:This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.