Cortistatin analogues for the treatment of inflammatory and/or immune diseases
The invention relates to cortistatin analogues and their uses, wherein at least one natural phenylalanine residue is replaced with a non-natural phenylalanine derivative. The compounds of the invention are peptide ligands with potential application in the diagnosis, prevention or therapy of those pa...
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| creator | Parente Dueña, Antonio Ponsati Obiols, Berta Fernández Carneado, Jimena Farrera-Sinfreu, Josep |
| description | The invention relates to cortistatin analogues and their uses, wherein at least one natural phenylalanine residue is replaced with a non-natural phenylalanine derivative. The compounds of the invention are peptide ligands with potential application in the diagnosis, prevention or therapy of those pathologies where receptors capable of binding to cortistatin, specific or shared with other molecules such as somatostatin and/or ghrelin (GHSR), are expressed, being in addition more stable in serum than cortistatin. |
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| title | Cortistatin analogues for the treatment of inflammatory and/or immune diseases |
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