Process for crystalline pemetrexed dipotassium salt

Process for crystalline pemetrexed dipotassium salt

Disclosed herein is a process for preparing crystalline Pemetrexed dipotassium (I) Form-SP9 characterized by X-ray powder diffraction pattern comprising at least 5 characteristic 2 ° peaks selected from the XRPD peak set of 5.0, 12.5, 17.2, 20.8, 22.4, 25.7, 26.9 and 27.9 ± 0.2 2 °, comprising the s...

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Hauptverfasser: AKSHAY KANT CHATURVEDI, BHAGAT RAJ PIPAL, GAYAM VENKATA REDDY
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator AKSHAY KANT CHATURVEDI
BHAGAT RAJ PIPAL
GAYAM VENKATA REDDY
description Disclosed herein is a process for preparing crystalline Pemetrexed dipotassium (I) Form-SP9 characterized by X-ray powder diffraction pattern comprising at least 5 characteristic 2 ° peaks selected from the XRPD peak set of 5.0, 12.5, 17.2, 20.8, 22.4, 25.7, 26.9 and 27.9 ± 0.2 2 °, comprising the steps of: (a) providing a solution of Pemetrexed dipotassium in water; (b) cooling the reaction mixture to temperature below 10 °C; (c) addition of a polar organic solvent to the reaction to obtain a reaction mass, wherein polar organic solvent is selected from methanol, ethanol, n-propanol, isopropanol, n-butanol, amyl alcohol or isoamyl alcohol; (d) treating the reaction mass with a secondary solvent, wherein secondary solvent is a (C3-C6) ketone solvent, selected from acetone, butanone or pentanone; and (e) isolating the crystalline material Pemetrexed dipotassium (I) Form-SP9.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Process for crystalline pemetrexed dipotassium salt
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