Pyridin-2(1h)-one derivatives as jak inhibitors

Pyridin-2(1h)-one derivatives as jak inhibitors

Provided are pyridin-2(1H)-one derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include (5)-3-(4-( 1-( 5-fluoropyridin-2-yl)ethylamino)pyrimidin-2-ylamino)pyridin-2(1H)-one and 3-(5-{ 6-{ [(1S)-1-(5-Fluoropyridin-2-...

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Bibliographische Detailangaben
Hauptverfasser: PAGES SANTACANA LLUIS MIQUEL, BACH TAÑA JORDI, EASTWOOD PAUL ROBERT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided are pyridin-2(1H)-one derivative compounds of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include (5)-3-(4-( 1-( 5-fluoropyridin-2-yl)ethylamino)pyrimidin-2-ylamino)pyridin-2(1H)-one and 3-(5-{ 6-{ [(1S)-1-(5-Fluoropyridin-2-yl)ethyl]amino} -2-[(2-oxo-1,2-dihydropyridin-3-yl)amino]pyrimidin-4-yl} -1,3-thiazol-2-yl)benzoic acid. The compounds are JAK inhibitors. The compounds may be useful in the treatment of cancers and immunological and inflammatory diseases.