Amylin peptides and derivatives and uses thereof
The disclosure relates to an amylin polypeptide conjugate comprising a polypeptide component linked to a duration enhancing moiety. The duration enhancing moiety is linear polyethylene glycol. The disclosure also relates to the use of such a conjugate for the treatment of eating disorder, insulin re...
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creator | SUN CHENGZAO SAMANT MANOJ P NERAVETLA SWETHA |
description | The disclosure relates to an amylin polypeptide conjugate comprising a polypeptide component linked to a duration enhancing moiety. The duration enhancing moiety is linear polyethylene glycol. The disclosure also relates to the use of such a conjugate for the treatment of eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyperlipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome. The polypeptide has the following sequence: Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Xaa-Ser-Ser-Xaa-Asn-Phe-Xaa- Xaa-Xaa-Xaa-Xaa-Lys-Thr-Xaa-Val-Gly-Lys-Lys-Thr-Tyr-X wherein X and the various Xaa groups are defined in the specification |
format | Patent |
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The duration enhancing moiety is linear polyethylene glycol. The disclosure also relates to the use of such a conjugate for the treatment of eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyperlipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome. The polypeptide has the following sequence: Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Xaa-Ser-Ser-Xaa-Asn-Phe-Xaa- Xaa-Xaa-Xaa-Xaa-Lys-Thr-Xaa-Val-Gly-Lys-Lys-Thr-Tyr-X wherein X and the various Xaa groups are defined in the specification</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150925&DB=EPODOC&CC=NZ&NR=618526A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150925&DB=EPODOC&CC=NZ&NR=618526A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SUN CHENGZAO</creatorcontrib><creatorcontrib>SAMANT MANOJ P</creatorcontrib><creatorcontrib>NERAVETLA SWETHA</creatorcontrib><title>Amylin peptides and derivatives and uses thereof</title><description>The disclosure relates to an amylin polypeptide conjugate comprising a polypeptide component linked to a duration enhancing moiety. The duration enhancing moiety is linear polyethylene glycol. The disclosure also relates to the use of such a conjugate for the treatment of eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyperlipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome. The polypeptide has the following sequence: Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Xaa-Ser-Ser-Xaa-Asn-Phe-Xaa- Xaa-Xaa-Xaa-Xaa-Lys-Thr-Xaa-Val-Gly-Lys-Lys-Thr-Tyr-X wherein X and the various Xaa groups are defined in the specification</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBwzK3MycxTKEgtKMlMSS1WSMxLUUhJLcosSyzJLIPyS4uBjJKM1KLU_DQeBta0xJziVF4ozc0g5-Ya4uyhm1qQH59aXJCYnJqXWhLvF2VmaGFqZOZoTFABAHO1Klg</recordid><startdate>20150925</startdate><enddate>20150925</enddate><creator>SUN CHENGZAO</creator><creator>SAMANT MANOJ P</creator><creator>NERAVETLA SWETHA</creator><scope>EVB</scope></search><sort><creationdate>20150925</creationdate><title>Amylin peptides and derivatives and uses thereof</title><author>SUN CHENGZAO ; SAMANT MANOJ P ; NERAVETLA SWETHA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ618526A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SUN CHENGZAO</creatorcontrib><creatorcontrib>SAMANT MANOJ P</creatorcontrib><creatorcontrib>NERAVETLA SWETHA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SUN CHENGZAO</au><au>SAMANT MANOJ P</au><au>NERAVETLA SWETHA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Amylin peptides and derivatives and uses thereof</title><date>2015-09-25</date><risdate>2015</risdate><abstract>The disclosure relates to an amylin polypeptide conjugate comprising a polypeptide component linked to a duration enhancing moiety. The duration enhancing moiety is linear polyethylene glycol. The disclosure also relates to the use of such a conjugate for the treatment of eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyperlipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis, osteoarthritis, or short bowel syndrome. The polypeptide has the following sequence: Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Xaa-Ser-Ser-Xaa-Asn-Phe-Xaa- Xaa-Xaa-Xaa-Xaa-Lys-Thr-Xaa-Val-Gly-Lys-Lys-Thr-Tyr-X wherein X and the various Xaa groups are defined in the specification</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | Amylin peptides and derivatives and uses thereof |
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