Macrocyclic compounds as protein kinase inhibitors
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...
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| creator | RIESCO FAGUNDO ROSARIO CONCEPCIÓN CEBRIÁN MUÑOZ DAVID ÁLVARO ÁLVAREZ ESCOBAR ROSA MARÍA RODRÍGUEZ HERGUETA ANTONIO PASTOR FERNÁNDEZ JOAQUÍN MARTÍN HERNANDO JOSE IGNACIO BLANCO APARICIO CARMEN GARCÍA GARCÍA ANA BELÉN |
| description | There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. |
| format | Patent |
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The invention also relates to combinations containing such compounds.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150731&DB=EPODOC&CC=NZ&NR=618157A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150731&DB=EPODOC&CC=NZ&NR=618157A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RIESCO FAGUNDO ROSARIO CONCEPCIÓN</creatorcontrib><creatorcontrib>CEBRIÁN MUÑOZ DAVID ÁLVARO</creatorcontrib><creatorcontrib>ÁLVAREZ ESCOBAR ROSA MARÍA</creatorcontrib><creatorcontrib>RODRÍGUEZ HERGUETA ANTONIO</creatorcontrib><creatorcontrib>PASTOR FERNÁNDEZ JOAQUÍN</creatorcontrib><creatorcontrib>MARTÍN HERNANDO JOSE IGNACIO</creatorcontrib><creatorcontrib>BLANCO APARICIO CARMEN</creatorcontrib><creatorcontrib>GARCÍA GARCÍA ANA BELÉN</creatorcontrib><title>Macrocyclic compounds as protein kinase inhibitors</title><description>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. 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The invention also relates to combinations containing such compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Macrocyclic compounds as protein kinase inhibitors |
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